Ma Shaohua

2009-2013   PhD, Cambridge University. Supervisor: Wilhelm T.S. Huck, Chris Abell FRS FMedSci.

2005-2009   B.Eng, Sun Yat-sen University 

2017.09 - now  Principal Investigator, Tsinghua-Berkeley Shenzhen Institute (TBSI) / Tsinghua Shenzhen International Graduate School (SIGS)

2013.11-2017.08   Postdoctoral Research Associate, Oxford University. Supervisor: Hagan Bayley FRS. 

Introduction of Mechanobiology 

Technology Advances for Regenerative Medicine

Design of Precision Medicine Platforms for Disease Diagnosis and Therapeutics

Organoids and Organ Printing 

Organ-on-a-Chip and Microfluidics

Organoid Transplantation and Regenerative Medicine 

Tissue Information Acquisition

[1]. Shengwei Jiang, Haoran Zhao, Weijie Zhang, Jiaqi Wang, Yuhong Liu, Yuanxiong Cao, Honghui Zheng, Zhiwei Hu, Shubin Wang, Yu Zhu, Wei Wang, Shuzhong Cui, Peter E. Lobie, Laiqiang Huang*, Shaohua Ma*, An automated organoid platform with inter-organoid homogeneity and inter-patient heterogeneity, Cell Reports Medicine (Cell Press), 2020, 1, 100161.

[2]. Haoran Zhao, Zitian Wang, Shengwei Jiang, Jiaqi Wang, Zhiwei Hu, Peter E. Lobie, Shaohua Ma*, Microfluidics synthesis of injectable angiogenic microgels, Cell Reports Physical Science (Cell Press), 2020, 1, 100047.

[3]. Yong Wang, Mengqi Ji, Shengwei Jiang, Xukang Wang, Jiamin Wu, Jintao Fan, Shaohua Ma*, Lu Fang*, Qionghai Dai*, Augmenting vascular disease diagnosis by vasculature-aware unsupervised learning, Nature Machine Intelligence, 2020, 2, 337–346.

[4]. Edgar A. Galan, Haoran Zhao, Xukang Wang, Qionghai Dai, Wilhelm Huck, Shaohua Ma*, Intelligent microfluidics: The convergence of machine learning and microfluidics in materials science and biomedicine, Matter (Cell Press), 2020, 3, 1893–1922.

[5]. Yichao Zheng, Yinheng Zhu, Mengqi Ji, Rongpin Wang, Xinfeng Liu, Mudan Zhang, ChooHui Qin, Lu Fang*, Shaohua Ma*, A Learning-based Model to Evaluate Hospitalization Priority in COVID-19 Pandemics, Patterns (Cell Press), 2020, 1, 100092.

[6]. Shaohua Ma*, Haoran Zhao, Edgar A. Galan, Integrating Engineering, Automation, and Intelligence to Catalyze the Biomedical Translation of Organoids, Advanced Biology, 2021, 4, accepted.

[7]. Weijie Zhang*, Donghui Li, Shengwei Jiang, Edgar A Galan, Laiqiang Huang*, Shaohua Ma*, Microfluidic droplets as structural templates for Matrigel to enable 1-week large organoid modeling, Chemical Engineering Science, 2021, 238, 116632.

[8]. L. Zeng, Q. Liao, H. Zhao, S. Jiang*, X. Yang, H. Tang, Q. He, X. Yang, S. Fang, J. He, W. Cui, L. Huang, Shaohua Ma, Shuzhong Cui*, Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids, Cancer Biology and Medicine, 2021. doi: 10.20892/j.issn.2095-3941.2020.0566.

[9]. Bing Xu, Yuanxiong Cao, Zheng Zheng, Edgar A. Galan, Zhiwei Hu, Jun Ge, Xinhui Xing, Shaohua Ma*, Injectable mesenchymal stem cell-laden Matrigel microspheres for endometrium repair and regeneration, Advanced Biology, 2021, 4, accepted.

[10]. Shaohua Ma*, Haoran Zhao, Edgar A. Galan, Modulating flow topology in microdroplets to control reaction kinetics, Advanced Biosystems, 2021, 4, 2000309.

[11]. Jiaqi Wang, Xiaowei Tang, Zitian Wang, Jiawei Li, Shaohua Ma*, Extracellular scaffold design for ultra-soft microtissue engineering, Light: Advanced Manufacturing, 2021, 2, 11.

[12]. Yifan Xing, Junyu Liu, Xiaojie Guo, Haipeng Liu, Wen Zeng, Yi Wang, Chong Zhang, Yuan Lu, Dong He, Shaohua Ma, Yonghong He, Xinhui Xing*, Engineering organoid microfluidic system for biomedical and health engineering: A review, Chinese Journal of Chemical Engineering, 2021,accepted. https://doi.org/10.1016/j.cjche.2020.11.013.

[13]. Yuanxiong Cao, Haoran Zhao, Shaohua Ma*, Cascade pumping overcomes hydraulic resistance and moderates shear conditions for slow gelatin fiber shaping in narrow tubes, iScience (Cell Press), 2020, 23, 101228.

[14]. Chengyong He, Fengkai Ruan, Shengwei Jiang, Jie Zeng, Hanying Yin, Rong Liu, Yongxing Zhang, Laiqiang Huang, Chonggang Wang, Shaohua Ma*, Zhenghong Zuo*, Black Phosphorus Quantum Dots Cause Nephrotoxicity in Organoids, Mice, and Human Cells, Small, 2020, 16, 2001371.

[15]. Xinlong Pang, Haoran Zhao, Shaohua Ma*, A microfluidics reaction system for a multi- component reaction with automation and high chemoselectivity, Advanced Intelligent System, 2020, 2, 1900191.

[16]. Swati Kaushik, Sonu Gandhi, Mehak Chauhan, Shaohua Ma, et al. Deepa Suhag*, Water-templated, Polysaccharide-rich, Bio-artificial 3D Microarchitectures as Extra-Cellular Matrix Bioautomatons, ACS Applied Materials & Interfaces, 2020, 12, 20912–20921.

[17]. Shaohua Ma*, Microfluidics tubing as a synthesizer for ordered microgel networks, Soft Matter, 2019, 15, 3848–3853.

[18]. Shaohua Ma*, Engineering inverse opals with enclosed voids via bottom-up assembly of double emulsions, Chemical Engineering Science, 2019, 205, 414-419.

[19]. Shaohua Ma*, Gelatin-based microfluidics device with the feature sizes smaller than 100 μm for the production of oil-in-water emulsions, Microfluidics & Nanofluidics, 2019, 23, 35.

[20]. Shaohua Ma*, N. Mukherjee, Microfluidics fabrication of soft microtissues and bottom-up assembly, Advanced Biosystems, 2018, 2, 1800119.

[21]. Shaohua Ma, N. Mukherjee, E. Mikhailova, H. Bayley, Gel microrods for 3D tissue printing, Advanced Biosystems, 2017, 1, 1700075.

[22]. Shaohua Ma, S. Balabani, W. T. S. Huck, Deformation of double emulsions under conditions of flow cytometry hydrodynamic focusing, Lab on a Chip, 2015, 15, 4291-4301.

[23]. Shaohua Ma, J. Sherwood, W. T. S. Huck, S. Balabani, The microenvironment of double emulsions in rectangular microchannels, Lab on a Chip, 2015, 15, 2327-2334.

[24]. Shaohua Ma, J. Sherwood, W. T. S. Huck, S. Balabani, On the flow topology inside droplets moving in rectangular microchannels, Lab on a Chip, 2014, 14, 3611-3620.

[25].J. Thiele, Y. Ma, S. M. C. Bruekers, Shaohua Ma, W. T. S. Huck, Designer hydrogels for cell cultures: A materials selection guide, Advanced Materials, 2014, 26, 125-148.

[26]. Shaohua Ma, M. Natoli, X. Liu, M. P. Neubauer, F. M. Watt, A. Fery, W. T. S. Huck, Monodisperse collagen-gelatin beads as potential platforms for 3D cell culturing, Journal of Materials Chemistry B 2013, 1, 5128-5136.

[27]. Shaohua Ma, J. Thiele, X. Liu, Y. Bai, C. Abell, W. T. S. Huck, Fabrication of Microgel Particles with Complex Shapes via Selective Polymerization of Aqueous Two-Phase System, Small 2012, 8, 2356-2360.

[28]. J. Thiele, V. Chokkalingam, Shaohua Ma, D. A. Wilson, W. T. S. Huck, Vesicle budding from polymersome templated by microfluidically prepared double emulsions, Materials Horizons 2014, 1, 96-101.