Chemistry and physics of materials with an emphasis on rational synthesis, hierarchical assembly and fundamental physical properties of nanoscale wires; nano-bioelectronics with a focus on real-time, ultra-sensitive detectors, revolutionary tools for single cell measurements, and three-dimensional innervation of synthetic tissue and organs; brain science with an emphasis on development of the new paradigms for long-term mapping and modulation of neural activity in live animals, studies of fundamental problems in neuroscience, including memory, learning and cognition, and the development of and translation of implants for the treatment of disease. Novel nano-bioelectronic interfaces, brain machine interfaces and the intersection of brain science with artificial intelligence represent active areas of interest expected to impact in significant ways both the treatment human diseas and human intelligence in the future.