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  • Biography

    Education

    09/2008- 01/2013, Ph.D., Organic Chemistry, Tsinghua University, China
    09/2005-07/2008, M.S., Medical Chemistry, Shenyang Pharmaceutical University, China
    09/2001-07/2005, B.S., Pharmaceutical Engineering, Qiqihar University, China



    Professional Experience

    2018-present, Assistant Professor, Graduate School at Shenzhen, Tsinghua University

    2015-2018, Postdoctoral associate, Department of chemistry, South University of Science and Technology of China (with Prof. Dr. Xin-Yuan Liu) and Dalian Institute of Chemical Physics, CAS, China (with Prof. Dr. Xingwei Li).
    2013-2015, Research Fellow, Department of chemistry, South University of Science and Technology of China (with Prof. Dr. Xin-Yuan Liu)



    Additional Positions

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  • Current Courses

    SUSTech Presidential Postdoctoral Fellowship (Top 10%), SUSTech, China. 2017.

    Master’s & Ph.D. Advising

  • Research Interests

    Synthesis methodology: Asymmetric radical fluoroalkyl reaction; new synthesis methods for chiral (fluorine) antitumor agents and research on their antitumor mechanisms.

    Projects

    National Natural Science Foundation of China Youth Fund Project, Catalytic Asymmetric Aminotrifluoro(thio)methylation and Aminofluorination of Unactivated Alkenes

    Research Output

  • Selected Publications

    [1]  Jin-Shun Lin, Tao-Tao Li, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Ling Lv, and XinYuan Liu*. Chiral Br?nsted Acid-Catalyzed Dynamic Kinetic Asymmetric  Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes. Angew. Chem. Int. Ed. 2019, DOI:10.1002/anie.201900955.

    [2]  Jin-Shun Lin, Tao-Tao Li, Ji-Ren Liu, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Yu-Long Guo, Xin Hong* and Xin-Yuan Liu*. Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three Component  Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes. J. Am. Chem. Soc. 2019, 141, 1074.Highlighted in Synfacts 2019, 15, 0255.

    [3]  Fu-Li Wang #, Xiao-Yang Dong, # Jin-Shun Lin, # Yang Zeng, Guang-Yuan Jiao, Qiang-Shuai Gu, Xiang-Qi Guo, Can-Liang Ma, Xin-Yuan Liu*. Catalytic Asymmetric Radical Diamination of Alkenes. Chem 2017. 3, 979. (# Co-first author) Highlighted in Chem 2017, 3, 919.

    [4]  Jin-Shun Lin, Fu-Li Wang, Xiao-Yang Dong, Wei-Wei He, Yue Yuan, Su Chen, Xin-Yuan Liu*. “Catalytic Asymmetric Radical Aminoperfluoroalkylation and Aminodifluoromethylation of Alkenes with Fluoroalkylsulfonyl Chlorides: A Versatile Platform for Enantioenriched-Fluoroalkyl Amines”. Nat. Commun. 2017, 8, 14841.

    [5]  Jin-Shun Lin, Xiao-Yang Dong, Tao-Tao Li, Na-Chuan Jiang, Bin Tan, and Xin-Yuan Liu*. “A Dual-Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes”. J. Am. Chem. Soc. 2016, 138, 9357. Highlighted in Synfacts, 2016, 1020. Highlighted in Chin. J. Org. Chem. 2016, 36, 2247.

    [6]  Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* and Xin-Yuan Liu*. “Br?nsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter”. Angew. Chem. Int. Ed. 2015, 54, 7847. Highlighted in Chin. J. Org. Chem., 2015, 35, 1802.

    [7]  Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu*. “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles”. Chem. Eur. J. 2014, 20, 1332. 

    [8]  Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan,* and Xin-Yuan Liu*. “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles”. J. Org. Chem. 2014, 79, 7084. 

    [9]  Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, and Xin-Yuan Liu*. “Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene”. Angew. Chem. Int. Ed. 2014, 53, 11890. Highlighted in Synfacts, 2014, 10, 1281.

    [10]  Lin Huang, Jin-Shun Lin, Bin Tan,* and Xin-Yuan Liu*. “Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam”. ACS Catal. 2015, 5, 2826. 

    [11]  Xue-Fei Li, Jin-Shun Lin, Jian Wang, Zhong-Liang Li, Qiang-Shuai Gu, Xin-Yuan Liu*. “Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Radical-Initiated Aminoarylation of Alkenes”. Acta Chim. Sinica, 2018, 76, 878.

    [12]  Xue-Fei Li, Jin-Shun Lin, Xin-Yuan Liu*. “Catalytic Radical Intramolecular Aminoperfluoroalkylation and Aminodifluoromethylation of Unactivated Alkenes with Fluoroalkylsulfonyl Chlorides”. Synthesis. 2017, 49, 4213.

    [13]  Taotao Li, Peng Yu, Yi-Meng Du, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu*.“Dual-Catalyzed Enantioselective Remote C?H Functionalization Triggered by Radical Trifluoromethylation of Alkenes: Highly Selective Formation of C?CF3 and C?C Bonds”. J. Fluorine Chem. 2017, 203, 210.

    [14]  Ping Song, Peng Yu, Jin-Shun Lin, Yang, N.-Y.; Liu, X.-Y. “Transition-Metal-Free β?C?H Bond Carbonylation of Enamides or Amides with a Trifluoromethyl Group as CO Surrogate for the Synthesis of 1,3-Oxazin-6-ones”. Org. Lett. 2017, 19, 1330.

    [15]  Lin Huang, Liu Ye, Xiao-Hua Li, Zhong-Liang Li, Jin-Shun Lin, and Xin-Yuan Liu*. “Stereoselective Radical Cyclization Cascades Triggered by Addition of Diverse Radicals to Alkynes to Construct 6(5)‐6‐5 Fused Rings”. Org. Lett. 2016, 18, 5284.

    [16]  Taotao Li, Peng Yu, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu,* Copper-Catalyzed Redox-Triggered Remote C–H Functionalization: Highly Selective Formation of C–CF3 and C–O Bonds”. Chin. J. Chem. 2016, 34, 490.

    [17]  Jin-Shun Lin, Xiuli Jin, Yiwen Bu, Deliang Cao, Nannan Zhang, Shangfu Li, Qinsheng Sun, Chunyan Tan, Chunmei Gao, Yuyang Jiang*. “Efficient Synthesis of RITA and its Analogues: Derivation of Analogues with Improved Antiproliferative Activity via Modulation of p53/miR-34a Pathway”.Org. Biomol. Chem. 2012. 10, 9734.

    [18]  Jin-Shun Lin, Feng Liu, Yuyang Jiang*. “Antisense Technologies Targeting Fatty Acid Synthetic Enzymes”.Recent Pat Anti-Canc, 2012; 7, 198. 

    [19]  Feng Zhu, Chu Qin, Lin Tao, Xin Liu, Zhe Shi, Xiaohua Ma, Jia Jiang, Ying Tan, Cheng Cui, Jin-Shun Lin, Chunyan Tan, Yuyang Jiang*, Yuzong Chen*. “Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting”. PNAS. 2011; 108, 12943.

    [20]  Jin-Shun Lin, Weige Zhang*, Nan Jiang, et al. “Total Synthesis of Bulbophylol-B”.J. Nat. Prod. 2008; 71, 1938. 


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  • Awards and Honors

    SUSTech Presidential Postdoctoral Fellowship (Top 10%), SUSTech, China. 2017.