Liu Xiao

2017 Ph.D., Department of Biology, University of Copenhagen, Denmark

2008 M.Sc, Department of Biochemistry and Molecular Biology, Nanjing University, China

2003 B.Sc., Department of Chemistry, Nanjing University, China

Nov 2020—present    Associate Professor, Tsinghua Shenzhen International Graduate School, Tsinghua University

Sept 2018—Oct 2020    Ph.D. Supervisor, School of Future Technology, University of Chinese Academy of Sciences

March 2017—Dec 2019    Head of Health and Aging Institute, BGI-research, BGI-Shenzhen

June 2008—Sept 2012    Operation Officer, Science and Technology Division, BGI-Shenzhen

Sept 2017—present    Adjunct Professor, Northwest University, China           

Topic editor of Frontiers in Immunology, reviewer of twenty scientific journals including Nature Communications, Nucleic Acids Research, and member of the American Association of Immunologists (AAI), and the Adaptive Immune Receptor Repertoire (AIRR) community.

1.     Translational research in cancer and immunological diseases

2.     T/B cell biomarker discovery in disease diagnosis and progression

1.     T and B cell receptor repertoire analysis;

2.     Single-cell multi-omics in immune microenvironment;

3.     Skin microbiota and immunology

Prof. Liu has published more than 70 peer-reviewed scientific papers in top journals including Nature, Nature Genetics and Genome Research, with total citations exceeding 20000 and a H-index of 35 (Google), of which more than 30 papers as the first or corresponding author. He is the editor or reviewer for many scientific journals, such as Nature Communications, Cell Research, Frontiers in Immunology etc., and is the inventor of more than 40 patents.

Please refer to full list at https://scholar.google.com/citations?user=87HQTwMAAAAJ&hl=zh-CN

# Co-first authors  *Corresponding author

1.    Jinghua Wu#, Xie Wang,…Changgang Li*, Xiao Liu*.Developing an Unbiased Multiplex PCR System to Enrich the TRB Repertoire Toward Accurate Detection in Leukemia. Frontiers in Immunology. 2020

2.    Xu Jiang#, Shiyu Wang#, … Xiao Liu*, Xuan Zhang*. Comprehensive TCR repertoire analysis of CD4 T-cell subsets in rheumatoid arthritis. Journal of Autoimmunity. 2020.(Correspondence, IF 7.5, JCR Q1)

3.    Gang Yi#, Yi Zhao#,… Xiao Liu*, Bin Li*. Single-cell RNA-seq unveils critical regulators of human FOXP3+ regulatory T cell stability. Science Bulletin. 2020.(Correspondence, IF 6.3, JCR Q1)

4.    Xiao Liu^#, Wei Zhang^#, Ming Zhao#, et al., T cell receptor β repertoires as novel diagnostic markers for systemic lupus erythematosus and rheumatoid arthritis. Annals of the Rheumatic Diseases. 2019. (IF 14.3, JCR Q1)

5.    Kai Gao#, Lingyan Chen#, …, Xiao Liu* and Xiu Qiu*. Germline-Encoded TCR-MHC Contacts Promote TCR V Gene Bias in Umbilical Cord Blood T Cell Repertoire. Frontiers in Immunology. 2019.(IF 4.7, JCR Q1)

6.    Yi Zhao, Xiao Li,…Yong Hou* and Xiao Liu*. Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood. GigaScience. 2019. (Correspondence, IF 4.7, JCR Q1)

7.    Ke Cao#, Jinghua Wu#,…Shaoheng he*, Xiao Liu*. T cell receptor repertoire data provides new evidence for hygiene hypothesis of allergic diseases. Allergy. 2019. (Correspondence, IF 6.8, JCR Q1)

8.    Wei Zhang#, Longlong Wang#, …Xiao Liu*. PIRD: Pan Immune Repertoire Database. Bioinformatics. 2019. (Correspondence, IF 4.5, JCR Q1)

9.    Wei Zhang, Xinyue Li, Longlong Wang,…I-Ming Wang* and Xiao Liu*. Identification of Variable and Joining germline genes and alleles for Rhesus macaque from B-cell receptor repertoires. The Journal of Immunology. 2019. (Correspondence, IF 4.7, JCR Q1)

10.    Mingdao Wang, Yan Li, …, Xiao Liu*. Alterations in the human gut microbiome associated with Helicobacter pylori infection. FEBS Open Bio. 2019 (Correspondence, IF 2, JCR Q2)

11.    Chen Huang, Xuemei Li, Jinghua Wu,…Xiao Liu*. The landscape and diagnostic potential of T and B cell repertoire in Immunoglobulin A Nephropathy. Journal of Autoimmunity. 2018.(Correspondence, IF 7.5, JCR Q1)

12.    Longlong Wang, Wei Zhang, Liya Lin,…Xiao Liu*. A comprehensive analysis of the T and B lymphocytes repertoire shaped by HIV vaccines. Frontiers in Immunology. Sept. 2018. (Correspondence, IF 5.5, JCR Q1)

13.    Xiao Liu*, Jinghua Wu. History, Applications and challenges of immune repertoire research. Cell Biology and Toxicology. Jan 2018.(Correspondence, IF 5.1, JCR Q1)

14.    Longfei Fu, Xinyang Li, Wei Zhang,.., Xiao Liu*. A comprehensive profiling of T- and B-lymphocyte receptor repertoires from a Chinese-origin rhesus macaque by high-throughput sequencing. PLoS ONE. 12(8):e0182733. August 2017 (Correspondence)

15.    Wei Zhang, Qiang Feng, Changxi Wang, … , Christian Datz*, Xiao Liu*.Characterization of the B Cell Receptor Repertoire in the Intestinal Mucosa and of Tumor-Infiltrating Lymphocytes in Colorectal Adenoma and Carcinoma. The Journal of Immunology. March 27, 2017, 1602039; DOI: https://doi.org/10.4049/jimmunol.1602039 (Cover article, Correspondence)

16.    Ting Wang, Changxi Wang, Jinghua Wu,…, Xiao Liu*. The different T-cell receptor repertoires in breast cancer tumors, draining lymph nodes, and adjacent tissues. Cancer Immunology Research. December 2016. DOI: 10.1158/2326-6066.CIR-16-0107 (Correspondence, IF 8.6, JCR Q1)

17.    Wei Zhang, I-ming Wang, Changxi Wang,…, Xiao Liu*. IMPre: an accurate and efficient software for prediction of T- and B-cell receptor germline genes and alleles from rearranged repertoire data. Frontiers in Immunology. doi: 10.3389/fimmu.2016.00457 (Correspondence)

18.    Ling-Hao Zhao, Xiao Liu, He-Xin Yan et al., Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nature Communications, 2016 Oct 5;7:12992. doi: 10.1038/ncomms12992. (co-first author)

19.    Jinghua Wu, Shan Jia, Changxi Wang,…, Xiao Liu*. Minimal Residual Disease Detection and Evolved IGH Clones Analysis in Acute B Lymphoblastic Leukemia Using IGH Deep Sequencing. Frontiers in Immunology. 04 October 2016 | http://dx.doi.org/10.3389/fimmu.2016.00403(Correspondence)

20.    Zheng Su, Junjie Zhang, Chanchal Kumar,…, Xiao Liu*. Species specific exome probes reveal new insights in positively selected genes in nonhuman primates. Scientific Reports. 2016 Sep 23;6:33876. doi: 10.1038/srep33876. (Correspondence)

21.    Xinyang Li, Xiaobo Duan, Kai Yang,…Xiao Liu*, Wen Tan*. Comparative Analysis of Immune Repertoires between Bactrian Camel's Conventional and Heavy-Chain Antibodies. PLOS ONE.2016 Sep 2;11(9):e0161801. doi: 10.1371/journal.pone.0161801. eCollection 2016. (Joint Correpondence)

22.    Xiao Liu, Wei Zhang, Xiaojing Zeng, et al,. Systematic Comparative Evaluation of Methods for Investigating the TCRβ Repertoire. PLoS ONE 11(3):e0152464 · March 2016. DOI: 10.1371/journal.pone.0152464

23.    Xiao Liu, Zesong Li, Zheng Su, et al., Novel Y-chromosomal microdeletions associated with non-obstructive azoospermia uncovered by high throughput sequencing of sequence-tagged sites (STSs). Scientific Reports. 6:21831 · February 2016. DOI: 10.1038/srep21831

24.    Wei Zhang, Zheng Su, Yuanping Du,…, Xiao Liu*. IMonitor: a robust pipeline for TCR and BCR repertoire analysis. Genetics. 201(2) · August 2015. DOI: 10.1534/genetics.115.176735 (Correspondence, IF 4.6, JCR Q1)

25.    Xuehan Zhuang, Yongping Li, Hongzhi Cao,…Xiao Liu*, Ling Wang*. Case report of a Li–Fraumeni syndrome-like phenotype with a de novo mutation in CHEK2. Medicine. 2016 Jul;95(29):e4251. doi: 10.1097/MD.0000000000004251. (Joint Correspondence)

26.    Sung ,W.K.#, Zheng, H.#, Li, S.#, Chen, R.#, Liu ,X.#, Li ,Y., Lee, N.P., Lee, W.H., Ariyaratne ,P.N., Tennakoon, C., et al.,Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nature Genetics, doi:10.1038/ng.2295, 2012 (co-first author)

27.    Zhengyan Kan^#, Hancheng Zheng^#, Xiao Liu^# et al. Whole genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Research. doi:10.1101/gr.154492.113 (co-first author)

28.    Jung Yong Hong^#, Xiao Liu^#, Mao Mao et al. Genetic Aberrations in Imatinib-Resistant Dermatofibrosarcoma Protuberans Revealed by Whole Genome Sequencing. PLOS ONE. 8(7): e69752. doi:10.1371/journal.pone.0069752 (co-first author)

Overseas High-Caliber Personnel (level B) in Shenzhen