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概况
教育经历
2009年10月-2013年10月,剑桥大学,化学专业,博士
2005年9月-2009年7月,中山大学,高分子材料与工程专业,工学学士
工作经历
2023年8月-至今,清华大学,深圳国际研究生院,长聘副教授,博导
2020年8月-2023年8月,清华大学,深圳国际研究生院,副教授,博导
2017年9月-2020年8月,清华大学,清华-伯克利深圳学院,助理教授,博导
2013年11月-2017年8月,牛津大学,博士后
学术兼职
《新型碳材料》杂志副主编(中科院煤化所主办);
社会兼职
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教学课程
精准医疗平台的设计及其疾病诊断和治疗应用,国际院
机械生物学介绍,国际院
再生医学技术进展,国际院
医学科学研究,国际院
研究生指导
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研究领域
面向药物研发和再生医疗的类器官合成生物技术与工程化应用
生物制造技术与装备研发
计算生物学
主要项目
[1] 国家自然科学基金委员会专项项目,基于神经-免疫-肿瘤类器官互作芯片的恶性肿瘤调控机制和治疗研究,2023-2025,
[2] 国家自然科学基金委员会面上项目,基于高保真肝癌类器官芯片的CAR-巨噬细胞M1/M2极化精准调控研究,2024-2027
[3] 国家自然科学基金委员会面上项目,胶质瘤器官芯片高通量建模及免疫治疗智能化评估,2020-2023
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代表性论文
[1] Ma, Shaohua*; Wang, Wanlong; Zhou, Jiaqi; Liao, Shangfeng; Hai, Cheng; Hou, Yibo; Zhou, Zhichun; Wang, Zitian; Su, Yingshi; Zhu, Yu; Dai, Xiaoyong; Zhao, Yuan; Liao, Sha; Cai, Yongde*; Xu, Xun*; Lamination-based Organoid Spatially Resolved Transcriptomics (LOSRT) Technique for Primary Lung and Liver Organoid Characterization, Proc. Natl. Acad. Sci., 2024, 121, e2408939121.
[2] Yang, Haowei; Li, Jiawei; Zheng, Yichao; Cao, Yuanxiong; Zhu, Yu; Sang, Gan; Galan, Edgar A; Ruan, Chuqian; Ma, Wilson M.J.; Dai, Xiaoyong; Cai, Yongde*; Ma, Shaohua*; Ultra-small tissue compatible organoid printer for rapid and controllable modeling of respiratory organoids, Device (Cell Press), 2024, 2: 100420.
[3] Zheng, Yichao; Han, Fei; Wu, Zhengyu; Wang, Bingjie; Chen, Xingchi; Boulouis, Caroline; Jiang, Yuebin; Ho, Amanda; He, Dan; Sia, Wan Rong; Mak, Jeffrey Y.W.; Fairlie, David P.; Wang, Lin-Fa; Sandberg, Johan K.; Lobie, Peter E.; Ma, Shaohua*; Leeansyah, Edwin*; MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis, Science Advances, 2024, 10: eadn6331.
[4] Zheng, Yichao; Tian, Qinyong; Yang, Haowei; Cai, Yongde; Zhang, Jiaxin; Wu, Yifen; Zhu, Shuo; Qiu, Zuocheng; Lin, Yimin; Hong, Jiangquan; Zhang, Yi; Dockrell, David; Ma, Shaohua*; Identification of nicotinic acetylcholine receptor for N-acetylcysteine to rescue nicotine induced injury using beating cilia in primary tissue derived airway organoids, Advanced Science, 2024, 2407054.
[5] Zhou, Jiaqi; Huang, Yi-chun; Wang, Wanlong; Li, Jiawei; Hou, Yibo; Yi, Ziqi; Yang, Haowei; Hu, Keer; Zhu, Yu; Wang, Zitian; Ma, Shaohua*; Chronotoxici-plate containing droplet engineered rhythmic liver organoids for drug toxicity evaluation, Advanced Science, 2024, 11: 2305925.
[6] Feng, Yilin; Fan, Jiaqi; Cheng, Yifan; Dai, Qionghai; Ma, Shaohua*; Stress regulates Alzheimer's disease progression via selective enrichment of CD8+ T cells, Cell Reports, 2023, 42(10): 113313.
[7] Tang, Xiaowei; Wang, Zitian; Khutsishvili, David; Cheng, Yifan; Wang, Jiaqi; Tang, Jiyuan; Ma, Shaohua*; Volumetric compression by heterogeneous scaffold embedding promotes cerebral organoid maturation and does not impede growth, Cell Systems, 2023, 14(10): 872-882.e3.
[8] Cao, Yuanxiong; Tan, Jiayi; Zhao, Haoran; Deng, Ting; Hu, Yunxia; Zeng, Junhong; Li, Jiawei; Cheng, Yifan; Tang, Jiyuan; Hu, Zhiwei; Hu, Keer; Xu, Bing; Wang, Zitian; Wu, Yaojiong; Lobie, Peter E; Ma, Shaohua*; Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration, Nature Communications, 2022, 13: 7463.
[9] Fan, Jiaqi; Feng, Yilin; Cheng, Yifan; Wang, Zitian; Zhao, Haoran; Galan, Edgar A.; Liao, Quanxing; Cui, Shuzhong; Zhang, Weijie; Ma, Shaohua*; Multiplex gene quantification as digital markers for extremely rapid evaluation of chemo-drug sensitivity, Patterns, 2021, 2: 100360.
[10] Jiang, Shengwei; Zhao, Haoran; Zhang, Weijie; Wang, Jiaqi; Liu, Yuhong; Cao, Yuanxiong; Zheng, Honghui; Hu, Zhiwei; Wang, Shubin; Zhu, Yu; Wang, Wei; Cui, Shuzhong; Lobie, Peter E.; Huang, Laiqiang*; Ma, Shaohua*; An automated organoid platform with inter-organoid homogeneity and inter-patient heterogeneity, Cell Reports Medicine, 2020, 1: 100161.
代表性著作
主要专利成果
国际专利: 1. H. Bayley, S. Ma, PCT/GB2017/051598, pending.
其他成果
1. Shaohua Ma, Nobina Mukherjee, Ellina Mikhailova, Hagan Bayley. Gel Microrods for 3D Tissue Printing. Advanced Biosystems, 2017, 1, 1700075. (Cover)
2. Ma S, Huck WT, Balabani S. Deformation of double emulsions under conditions of flow cytometry hydrodynamic focusing. Lab on a Chip, 2015, 15, 4291-4301. (Cover)
3. Ma S, Sherwood JM, Huck WT, Balabani S. The microenvironment of double emulsions in rectangular microchannels. Lab on a Chip, 2015, 15, 2327-2334.
4. Ma S, Sherwood JM, Huck WT, Balabani S. On the flow topology inside droplets moving in rectangular microchannels. Lab on a Chip, 2014, 14, 3611-3620.
5. Thiele J, Ma Y, Bruekers SM, Ma S, Huck WT. 25th anniversary article: Designer hydrogels for cell cultures: a materials selection guide. Advanced Materials, 2014, 26, 125-148.
6. J. Thiele, V. Chokkalingam, S. Ma, D. A. Wilson, W. T. S. Huck, Vesicle budding from polymersome templated by microfluidically prepared double emulsions. Materials Horizons 2014, 1, 96-101.
7. S. Ma, M. Natoli, X. Liu, M. P. Neubauer, F. M. Watt, A. Fery, W. T. S. Huck, Monodisperse collagen-gelatin beads as potential platforms for 3D cell culturing. Journal of Materials Chemistry B 2013, 1, 5128-5136.
8. S. Ma, J. Thiele, X. Liu, Y. Bai, C. Abell, W. T. S. Huck, Fabrication of Microgel Particles with Complex Shapes via Selective Polymerization of Aqueous Two-Phase System, Small 2012, 8, 2356 – 2360.
9. B. Zhang, X. Chen, S. Ma, Y. Chen, J. Yang, M. Zhang, The Enhancement of photoresponse of an ordered inorganic-organic hybrid architecture by increasing interfacial contacts, Nanotechnology 2010, 21, 065304.
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荣誉奖项