-
Biography
Education
Jan. 2014 - Feb. 2018, Ph.D. in Bioinorganic Chemistry, The University of Hong Kong, Hong Kong, P.R. China
Sep. 2012 - Dec. 2013, Analytical Chemistry, Wuhan Institute of Technology (Supervisor:Prof. Rong Chen)
Sep. 2008 - Jul. 2012, B. Eng. In Food Science and Engineering, Wuhan Institute of Technology (Supervisor:Prof. Hongzhe Sun, Dr. Richard Yi-Tsun Kao)
Professional Experience
Feb. 2022 - present, Assistant Professor, Tsinghua Shenzhen International Graduate School, China
Oct. 2018 - Oct. 2021, Postdoctoral Research Fellow, The University of Hong Kong
Mar. 2018 - Sep. 2021, Research Assistant, The University of Hong Kong
Additional Positions
Infectious Diseases Reviews, Editorial Board Member
Frontiers in Environmental Chemistry, Guest Editor
Frontiers in Chemistry, Guest Editor
Opening
Personal Webpage
Download CV
-
Current Courses
Cell Culture Engineering
Master’s & Ph.D. Advising
-
Research Interests
Wang Runming has long been engaged in research in the interdisciplinary fields of bioinorganic chemistry, biology and microbiology. The research focus of Wang Runming's research group is mainly on metallo-related chemical biology, systems biology, and synthetic biology. In the early stage, through the research and development of innovative drugs and related (nano) chemical/biological tools, the structure and function of key metalloproteins (enzymes) in pathogenic bacteria, viruses, and eukaryotic cells were regulated, and the new infectious diseases (antimicrobial resistance) were overcome. Some achievements have been made in the research of major scientific issues such as drug infection and COVID-19), malignant tumors and aging. Wang Runming presided over or participated in a number of domestic and international fund projects. Has published more than 20 SCI papers in related fields, 2 highly cited papers, with a total number of citations > 1800. In the past five years, as the first author (including equal contribution) and corresponding author in Nat. Microb., Nat. Comm. (2 papers), Proc. Natl. Acad. Sci. U.S.A, Chem. Sci., iScience, Chem. Eng . J. and other international journals published papers. Authorized/published 4 USPTO/PCT patents and 1 Chinese patent. Relevant research work has been invited to hold media conferences for many times and has been widely reported by dozens of Chinese and foreign media (Xinhuanet, CGTV, Reuters, Reference News, Phoenix.com, South China Morning Post, Science Daily, etc.); new crown drug-related research was selected into the 2020 Annual Top 10 Innovation and Technology News in Hong Kong. Invited to participate in many domestic and foreign academic conferences and give oral reports.
We solemnly invite all aspiring master students, doctoral students and postdoctoral fellows to join Dr. Wang Runming's research team!
Projects
Co-PI, ‘Discovery of metallo-agents as antimicrobial resistance breakers’, PROCORE-France/Hong Kong Joint Research Scheme 2019/20 (Ref No: F-HKU704/19), 2020-2022.
Co-I, ‘Development of novel inhibitors for combatting COVID-19 infection’, Seed Funding for COVID-19, The University of Hong Kong, 2020-2021.
Key member, ‘Development of novel inhibitors for combatting SARS-CoV- 2 infection’, Innovation and Technology Fund (Ref No:ITS/278/20), 2021-2023.
Key member, “Discovery and preclinical evaluation of bismuth(III) complexes with porphyrins and thiolates as new antagonists against side-effect of cisplatin”, Innovation and Technology Fund (Ref No: ITS/124/17), 2016-2018.
Key member, “Combination approach to combat metallo-β-lactam positive superbugs”, Research Impact Fund 2018/2019 (Ref No: R7070-18), 2019-2024.
Research Output
-
Selected Publications
# Co-first author, * Correspondence author
1. Qi Z#, Wang R#, Wang M, Liu C, Koohi-Moghadam M, Wang H, Ho P-L, Li H, Sun H*,“Re-sensitization of mcr carrying multidrug resistant bacteria to 3 colistin by silver, Proc. Natl. Acad. Sci. U.S.A., 2022, 119, e2119417119.
2. Wang R#, Chan J. F-W#, Wang S#, Li H, Zhao J, Ip K-Y, Zuo Z, Yuen K-K, Yuan S*, Sun H*, Orally administrated bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy. Chem. Sci., 2022, 13, 2238-2248 [Back cover]
3. Yuan S#, Wang R#, Chan FW#, Zhang J, Cheng T, Chik KH, Ye Z-W, Wang S, Jin L, Li H, Jin DY, Yuen KY*, Sun H*, Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters, Nat. Microbiol, 2020, 5, 1439–1448. [Local Top Ten innovation and technology news in 2020]]
4. Sun H# *, Zhang Q#, Wang R# *, Wang H, Wong YT, Wang M, Hao Q, Yan A, Kao YT, Ho PL, Li H, Resensitizing superbugs carrying both blaMBL and mcr genes to antibiotics by auranofin, Nat. Commum., 2020, 11, 5263.
5. Wang R, Wang S, Chan S, Wang Y, Zhang Y, Zuo Z, Chan CF, Li H, Sun H*, Bismuth porphyrin antagonizes cisplatin-induced nephrotoxicity via unexpected metallothionein-independent mechanisms, iScience, 2020, 23, 101054.
6. Wang R#, Lai TP#, Gao P#, Zhang H#, Ho PL, Woo PC, Ma G, Kao RYT, Li H, Sun H*. Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors, Nat. Commum., 2018, 9, 439.[Highly cited paper]
7. WangR#, Cheng G#, Dai Z, Ding J, Liu Y, Chen R*, Ionic liquid-employed synthesis of Bi2E3 (E=S, Se, and Te) hierarchitectures: the case of Bi2S3 with superior visible-light-driven Cr(VI) photoreduction capacity, Chem. Engineer. J., 2017, 327, 371-386.
8. Chan S#, Wang R#, Man K, Nicholls J, Li H, Sun H*, Chan GC*.Transl Oncol. 2016, 12, 788-799
9. Yuan S, Yin X, Meng X, Chan F-W, Ye Z-W, Riva L, Pache L, Chan C-Y, Lai P-M, Chan C-S, Poon K-M, Lee C-Y, Matsunaga N, Pu Y, Yuen C-K, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau C-Y, Sit KY, Au W-K, Wang R, Zhang Y-Y, Tang Y, Clausen T, Pihl J, Oh J, Sze K-H, Zhang J, Chu H, Kok K-H, Wang D, Cai X-H, D. Esko J, Hung F-N, Li R, Chen H, Sun H, Jin D-Y, Sun R, K. Chanda S, Yuen K-Y. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2, Nature, 2021, 593, 418–423.
10. Li H, Wang R, Sun H. Systems approaches for unveiling the mechanism of action of bismuth drugs: new medicinal applications beyond helicobacter pylori infection accounts of chemical research, Acc. Chem. Res. 2019 52, 216-227
Other relevant publications can be accessed via the following ways:
Google scholar link: https://scholar.google.com/citations?user=DWNINfAAAAAJ&hl=en&oi=ao
ORCID link: https://orcid.org/0000-0001-8525-5659
Research gate link:https://www.researchgate.net/profile/Runming-Wang
Books
1. Wang R, Li H, Ip K-Y, Sun H. Chapter Six - Bismuth drugs as antimicrobial agents, Academic Press; 1st edition, 2020
2. Wang R, Li H, Sun H. Bismuth: Environmental Pollution and Health Effects, Elsevier, 2019
Patents
(1) Hongzhe Sun; Richard Yi Tsun Kao; Runming Wang; Tsz Pui Lai; Hongmin Zhang; Hongyan Li ; Bismuth (III) compounds and methods thereof, 2019-2-12, USPTO, US10201518B2,Granted.
(2) Hongzhe Sun; Chi-Fung Godfrey Chan; Shing Chan; Runming Wang ; Bismuth(III) complexes as adjuvants in the treatment of cancer using platinum-based chemotherapy, 2023-01-17, USPTO, US11554138B2,Granted.
(3) Hongzhe Sun; Pak-Leung Ho; Runming Wang; Hongyan Li; Qi Zhang ; Silver-/gold-compounds and methods thereof, 2019-8-23, WIPO, PCT/CN2020/110444,filed.
(4) Hongzhe Sun; Kwok-Yung Yuen; Shuofeng Yuan; Runming Wang; Hongyan Li; Fuk-Woo Chan; Tianfan Cheng; Suyu Wang ; Compositions and methods for treating a SARS-CoV-2 infection, 2021-5-31, USPTO, 63/032,888,filed.
(5) 孙红哲; 高一村; 王润铭; 黎梓培;张宏民; 李洪艳,中国, ZL201780059904.3,Granted.
Others
-
Awards and Honors
1. 2022 MIT Technology Review Innovators Under 35 Asia Pacific finalist.
2. 2022National Overseas High-level Talents (Youth) Project receiver.
3. 2022Pengcheng Peacock Project special position B talent.
4. 2021 2020 Annual Top 10 Innovation and Technology News in Hong Kong.
5. 2021年Faculty Knowledge Exchange (KE) Award (Team),The University of Hong Kong
6. 2021年Global Young Scientists Summit 2021,Singapore(virtual meeting)
7. 2021年1st HKU-Pasteur Research Pole Fellowship, Hong Kong, (declined)
8. 2018年Best Oral Presentation Award,9th Asian Biological Inorganic Chemistry Conference, Singapore
9. 2016年Royal Society of Chemistry Books Awards of 8th Asian Biological, Auckland, New Zealand
10. 2015年Outstanding Teaching Assistant, The University of Hong Kong, Hong Kong