Contact information

Tel: 0755-86540412

Email:

Address: UP-1509, Energy and Environment Building

Office Hours:

  • 个人简历
  • 教学
  • 研究领域
  • 研究成果
  • 奖励荣誉
  • Biography

    Hao joined Tsinghua Shenzhen International Graduate School as an Assistant Professor in January 2023. Hao was born and raised in the Hubei province of China. He attended Tianjin University for her undergraduate education (2008), majoring in Materials Chemistry. Hao did his Ph.D. study (2012-2018) with Prof. Feiyu Kang in the School of Materials Science and Engineering at Tsinghua University while co-mentored by Prof. Si-Shen Feng from the National University of Singapore. Hao did her postdoctoral training with Prof. Seok-Hyun Yun at the Harvard Medical School & Massachusetts General Hospital at Harvard University from March 2019 to December 2022.

     

    Hao is interested in exploiting the understanding of tissue, cell, and molecule of diseases to design biomaterials that affect, potentiate, and read specific cell functions, including more effective and practical molecular therapies, molecular imaging, and spatiotemporal single-cell omics. Hao's previous research focuses on efficiently using living light by constructing multi-specific photonic biomaterials for molecular imaging, phototherapy, and single-cell analysis for cancer. In recent five years, Hao published or preprinted ten papers as first author or corresponding author on nanomedicine, molecular imaging, and single-cell analysis in prestigious top-ten journals such as Adv. Mater., Biomaterials, and Adv. Funct. Mater. In addition, Hao independently led and completed an NIH R01 grant and participated in NIH Director's Transformative Research Award as a key member of Yun Lab at Harvard Medical School.


    Education

    Sep. 2012 - Jul. 2018, MSc & Ph.D. in Materials Science and Engineering, Tsinghua University, China

    Sep. 2008 - Jul. 2012, B.S. in Materials Chemistry, Tianjin University, China


    Professional Experience

    Jan. 2023 - present, Assistant Professor, Tsinghua-Shenzhen International Graduate School, Tsinghua University, China

    Mar. 2019 - Dec. 2022, Postdoctoral Research Fellow, Harvard Medical School & Massachusetts General Hospital, USA

    Sep. 2018 - Jan. 2019, Research Assistant, School of Materials Science & Engineering, Tsinghua University, China


    Additional Positions

    Peer reviewer of Biomaterials, Theranostics, Advanced Healthcare Materials, Frontiers in Immunology, Biomedical microdevices, Nanomedicine, etc.


    Opening

    Personal Webpage

    Download CV

  • Current Courses

    Master’s & Ph.D. Advising

  • Research Interests

    1.Massively multiplexed cell tagging and single-cell analysis: Development of multiplexed 2D quantum dots and related biotech of multiplexed flow cytometry and sorting. Development of multiplexed laser particles and related biotech of in vivo cell tracking or tracing.

    2.In vivo precise, local delivery of molecular and cellular tools: Development of efficient and accurate drug delivery platform to local deliver gene editing tool.

    3.Spatiotemporal single-cell omics: Development of flexible, patch-type single-cell labeling materials & devices and applications for spatial single-cell omics. Development and application of spatiotemporal single-cell omics-related biomaterials, biotech, and algorithms.

    Opening Positions: We are looking for passionate, highly motivated, ambitious and creative young scientists to be part of our team.


    Projects

    Research Output

  • Selected Publications

    Selected published in the past five years:

    [1]     H. Yan, XD Sun*, J Tian*, FY Kang*, et al. Planted graphene quantum dots for targeted, enhanced tumor imaging and long-term visualization of local pharmacokinetics. Advanced Materials, 2023: 2210809.

    [2]     H. Yan, SH Yun*, et al. All-natural-molecule, self-luminescent photodynamic therapy results in complete tumor regression and prevents metastasis, Biomaterials, 2023: 122079.

    [3]     Q. Wang, JY. Wang, H. Yan*, et al. An ultra-small bispecific protein augments tumor penetration and treatment for pancreatic cancer. European Journal of Nuclear Medicine and Molecular Imaging, 2023: 1-15.

    [4]     Q. Wang#, H. Yan# (co-first author), J Tian*, XM Zhao* et al. Construction of a novel bispecific fusion protein to enhance targeting for pancreatic cancer imaging, Biomaterials. 2020, 255: 12061-12070.

    [5]     H. Yan, FY Kang*, et al. Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer, Nanoscale, 2019, 2: 706-716.

    [6]     Q. Wang#, H. Yan#(co-first author), J Tian*, XM Zhao* et al. A novel plectin/integrin-targeted bispecific molecular probe for magnetic resonance/near-infrared imaging of pancreatic cancer, Biomaterials. 2018, 183: 173-184.

    [7]     H. Yan, J Tian*, FY Kang*, et al. All-in-One Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration, Advanced Functional Materials. 2018, 1705710.

    [8]     H. Yan, XD Sun*, FY Kang*, et al. General synthesis of high-performing magneto-conjugated polymer core-shell nanoparticles for multifunctional theranostics, Nano Research. 2017, 10:704-717.


    Books

    Patents

    Others

  • Awards and Honors

    Excellent Student Leader (graduate) at Tsinghua University (2013)

    Outstanding Undergraduate of Tianjin University & Tianjin (2012)