Contact information

Tel: 13522067013


Address: Information Building No. 1208

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  • 个人简历
  • 教学
  • 研究领域
  • 研究成果
  • 奖励荣誉
  • Biography


    Sep. 2009 - Dec. 2014, Ph.D. in Chemical Engineering, South China University of Technology, Guangzhou, China

    Oct. 2012 - Oct. 2013, Visiting Ph.D. student, Ludwig-Maximilians-Universität München, Munich, Germany 

    Sep. 2005 - Jun. 2009, B.E. in Chemical Engineering, Southwest University for Nationalities, Chengdu, China

    Professional Experience

    Dec.2023-present, Associate Professor, Tsinghua Shenzhen International Graduate School, China

    May. 2021 - Dec.2023, Assistant Professor/Principal Investigator, Tsinghua Shenzhen International Graduate School, China

    Jun. 2019 - Dec. 2020, Postdoctoral Associate, Singapore-MIT Alliance for Research and Technology, Singapore

    Sept. 2016 - May. 2019, Postdoctoral Research/Research Associate, Washington State University, USA

    Jan. 2015 - Aug. 2016, Assistant Professor, National Center for Nanoscience and Technology, China 

    Additional Positions

    Guest Editor of International Journal of Polymer Science

    Invited reviewer of Pharmaceutics and Nanomaterials


    Personal Webpage

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  • Current Courses

    Biophysical Chemistry, Experimental Biology

    Master’s & Ph.D. Advising

    Bioresponsive polymer, targeted drug delivery and controlled release system, biopharmaceutical science

  • Research Interests

    Bioresponsive polymer, targeted drug delivery and controlled release system, biopharmaceutical science


    Our researches are focused on designing and generating multifunctional bioengineered stimuli-responsive biomedical vehicle and strategies used to efficiently and effectively prevent and treat some diseases, e.g. cancer, infection, autoimmune diseases. There are four major research interests:

    1) Design and synthesis of poly(β-amino ester)-based materials library

    2) Development of neutrophil-mediated drug delivery system for immunoregulation to treat diseases like cancer and neuroinflammation

    3) Development of polycationic polymer-based therapeutics for antimicrobial resistance to improve the infection treatment

    4) Development of microneedle patch for transdermal drug delivery and skin health engineering

    Research Output

  • Selected Publications

    [1]  Yun Hao Feng, Wei Xin Guo, Xiaobin Li, Jiahui Liu, Vahideh Nosrati-Siahmazgi, Maryam Toolabi, Wen Min Fei, Yong Cui, Bo Zhi Chen, Mohammad-Ali Shahbazi, Li Juan Zhang, Can Yang Zhang*, Xin Dong Guo*, Strategies to prevent water soluble drug leakage from nanovesicles in blood circulation: A coarse-grained molecular study, Chemical Engineering Science, 2023, 276, 118715

    [2] Zhiguo He, Can Yang Zhang*, Yu Lei*, Guolin Song, Youwei Yao, Plasmonic nanomaterials: A versatile phototheranostic platform of cancers, Materials Today, 2023, 62, 168-189. (Front Cover Article)

    [3] Xiaobin Li, Junyu Liu, Haihong Chen, Yaxin Chen, Yi Wang, Can Yang Zhang*, Xin-Hui Xing*, Multi-functional engineered polypeptide-based drug delivery systems for improved cancer therapy, Green Chemical Engineering, 2023, 4, 173-188.

    [4] Yaxin Chen, Duotian Qin, Jianhua Zou, Xiaobin Li, Xin Dong Guo, Yi Tang, Chuang Liu, Wei Chen, Na Kong, Can Yang Zhang*, Wei Tao*, Living Leukocyte-Based Drug Delivery Systems, Advanced Materials, 2023, 35, 2207787. (Front Cover Article)

    [5] Hai-Hong Chen, Wei Li, Yi Wang, Bing Xu, Xi Hu, Xiaobing Li, Junyu Liu, Chong Zhang, Can Yang Zhang, Xin-Hui Xing*, Mining and Validation of Novel Hemp Seed-Derived DPP-IV-Inhibiting Peptides Using a Combination of Multi-omics and Molecular Docking, Journal of Agricultural and Food Chemistry, 2023, 71, 9164-9174.

    [6] Wei Li, Hai-Hong Chen, Bing Xu, Yi Wang, Can Yang Zhang, Yong Cao, Xin-Hui Xing*, Research progress on classification, sources and functions of dietary polyphenols for prevention and treatment of chronic diseases, Journal of Future Foods, 2023, 3-4, 75-98.

    [7] Yan Wang, Juan Li, Jinping Shi, Junyu Liu, Can Yang Zhang*, Graphene-based nanomaterials for cancer therapy and anti-infections, Bioactive Materials. 2022, 14, 335-349.

    [8] Jinping Shi, Juan Li, Yan Wang, Can Yang Zhang*, TiO2-based Nanosystem for Cancer Therapy and Antimicrobial Treatment: A Review, Chemical Engineering Journal, 2022, 431, 133714. (ESI Highly Cited Paper)

    [9] Junyu Liu, Xiaobin Li, Xiaopeng Zhang, Runming Wang, Sanyang Han, Peiwu Qin*, Xin-Hui Xing, Can Yang Zhang*, Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome, Journal of Future Foods, 2022, 2, 307-325.

    [10]  Wen Xuan Li, Xiao Peng Zhang, Bo Zhi Chen, Wen Min Fei, Yong Cui*, Can Yang Zhang*,  Xin Dong Guo*, An update on microneedle-based systems for diabetes, Drug Delivery and Translational Research. 2022, 1-12.

    [11]  Yun Hao Feng, Bo Zhi Chen, Wen Min Fei, Yong Cui, Can Yang Zhang*, Xin Dong Guo*, Mechanism studies on the cellular internalization of nanoparticles using computer simulations: A review, AIChE Journal, 2022, e17507.

    [12]  Jinping Shi#, Juan Li#, Yan Wang, Xiaobin Li, Can Yang Zhang*, TiO2-based Nanosystem for Cancer Therapy and Antimicrobial Treatment: A Review. Chemical Engineering Journal. 2021, 431, 133714.

    [13]  黄龙;曾文;徐冰;张灿阳;马少华;张翀;王怡*;邢新会*, 口服多糖靶向药物递送体系在结肠疾病治疗中的应用研究进展, 药学学报, 2021, 1073. (IF 11.413). Q1

    [14]  Can Yang Zhang, Xinyue Dong, Jin Gao, Wenjing Lin, Ze Liu, Zhenjia Wang*, Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke, Science Advances, 2019, 5(11), eaax7964. (IF 14.136). Q1

    [15]  Can Yang Zhang, Wenjing Lin, Jin Gao, Xutong Shi, Maryam Davaritouchaee, Amy Nielsen, Rock Mancini, Zhenjia Wang*. pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury, ACS Applied Materials & Interfaces, 2019, 11(18), 16380-16390.




  • Awards and Honors

    Overseas High-Caliber Personnel Project (Peacock)