Zhang Canyang

Sep. 2009 - Dec. 2014, Ph.D. in Chemical Engineering, South China University of Technology, Guangzhou, China

Oct. 2012 - Oct. 2013, Visiting Ph.D. student, Ludwig-Maximilians-Universität München, Munich, Germany 

Sep. 2005 - Jun. 2009, B.E. in Chemical Engineering, Southwest University for Nationalities, Chengdu, China

Dec.2023-present, Associate Professor, Tsinghua Shenzhen International Graduate School, China

May. 2021 - Dec.2023, Assistant Professor/Principal Investigator, Tsinghua Shenzhen International Graduate School, China

Jun. 2019 - Dec. 2020, Postdoctoral Associate, Singapore-MIT Alliance for Research and Technology, Singapore

Sept. 2016 - May. 2019, Postdoctoral Research/Research Associate, Washington State University, USA

Jan. 2015 - Aug. 2016, Assistant Professor, National Center for Nanoscience and Technology, China 

Guest Editor of International Journal of Polymer Science

Invited reviewer of Pharmaceutics and Nanomaterials

Biophysical Chemistry, Experimental Biology

Bioresponsive polymer, targeted drug delivery and controlled release system, biopharmaceutical science

Bioresponsive polymer, targeted drug delivery and controlled release system, biopharmaceutical science

Our researches are focused on designing and generating multifunctional bioengineered stimuli-responsive biomedical vehicle and strategies used to efficiently and effectively prevent and treat some diseases, e.g. cancer, infection, autoimmune diseases. There are four major research interests:

1) Design and synthesis of poly(β-amino ester)-based materials library

2) Development of neutrophil-mediated drug delivery system for immunoregulation to treat diseases like cancer and neuroinflammation

3) Development of polycationic polymer-based therapeutics for antimicrobial resistance to improve the infection treatment

4) Development of microneedle patch for transdermal drug delivery and skin health engineering

[1]  Yun Hao Feng, Wei Xin Guo, Xiaobin Li, Jiahui Liu, Vahideh Nosrati-Siahmazgi, Maryam Toolabi, Wen Min Fei, Yong Cui, Bo Zhi Chen, Mohammad-Ali Shahbazi, Li Juan Zhang, Can Yang Zhang*, Xin Dong Guo*, Strategies to prevent water soluble drug leakage from nanovesicles in blood circulation: A coarse-grained molecular study, Chemical Engineering Science, 2023, 276, 118715

[2] Zhiguo He, Can Yang Zhang*, Yu Lei*, Guolin Song, Youwei Yao, Plasmonic nanomaterials: A versatile phototheranostic platform of cancers, Materials Today, 2023, 62, 168-189. (Front Cover Article)

[3] Xiaobin Li, Junyu Liu, Haihong Chen, Yaxin Chen, Yi Wang, Can Yang Zhang*, Xin-Hui Xing*, Multi-functional engineered polypeptide-based drug delivery systems for improved cancer therapy, Green Chemical Engineering, 2023, 4, 173-188.

[4] Yaxin Chen, Duotian Qin, Jianhua Zou, Xiaobin Li, Xin Dong Guo, Yi Tang, Chuang Liu, Wei Chen, Na Kong, Can Yang Zhang*, Wei Tao*, Living Leukocyte-Based Drug Delivery Systems, Advanced Materials, 2023, 35, 2207787. (Front Cover Article)

[5] Hai-Hong Chen, Wei Li, Yi Wang, Bing Xu, Xi Hu, Xiaobing Li, Junyu Liu, Chong Zhang, Can Yang Zhang, Xin-Hui Xing*, Mining and Validation of Novel Hemp Seed-Derived DPP-IV-Inhibiting Peptides Using a Combination of Multi-omics and Molecular Docking, Journal of Agricultural and Food Chemistry, 2023, 71, 9164-9174.

[6] Wei Li, Hai-Hong Chen, Bing Xu, Yi Wang, Can Yang Zhang, Yong Cao, Xin-Hui Xing*, Research progress on classification, sources and functions of dietary polyphenols for prevention and treatment of chronic diseases, Journal of Future Foods, 2023, 3-4, 75-98.

[7] Yan Wang, Juan Li, Jinping Shi, Junyu Liu, Can Yang Zhang*, Graphene-based nanomaterials for cancer therapy and anti-infections, Bioactive Materials. 2022, 14, 335-349.

[8] Jinping Shi, Juan Li, Yan Wang, Can Yang Zhang*, TiO2-based Nanosystem for Cancer Therapy and Antimicrobial Treatment: A Review, Chemical Engineering Journal, 2022, 431, 133714. (ESI Highly Cited Paper)

[9] Junyu Liu, Xiaobin Li, Xiaopeng Zhang, Runming Wang, Sanyang Han, Peiwu Qin*, Xin-Hui Xing, Can Yang Zhang*, Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome, Journal of Future Foods, 2022, 2, 307-325.

[10]  Wen Xuan Li, Xiao Peng Zhang, Bo Zhi Chen, Wen Min Fei, Yong Cui*, Can Yang Zhang*,  Xin Dong Guo*, An update on microneedle-based systems for diabetes, Drug Delivery and Translational Research. 2022, 1-12.

[11]  Yun Hao Feng, Bo Zhi Chen, Wen Min Fei, Yong Cui, Can Yang Zhang*, Xin Dong Guo*, Mechanism studies on the cellular internalization of nanoparticles using computer simulations: A review, AIChE Journal, 2022, e17507.

[12]  Jinping Shi^#, Juan Li^#, Yan Wang, Xiaobin Li, Can Yang Zhang*, TiO₂-based Nanosystem for Cancer Therapy and Antimicrobial Treatment: A Review. Chemical Engineering Journal. 2021, 431, 133714.

[13]  黄龙;曾文;徐冰;张灿阳;马少华;张翀;王怡*;邢新会*, 口服多糖靶向药物递送体系在结肠疾病治疗中的应用研究进展, 药学学报, 2021, 1073. (IF 11.413). Q1

[14]  Can Yang Zhang, Xinyue Dong, Jin Gao, Wenjing Lin, Ze Liu, Zhenjia Wang*, Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke, Science Advances, 2019, 5(11), eaax7964. (IF 14.136). Q1

[15]  Can Yang Zhang, Wenjing Lin, Jin Gao, Xutong Shi, Maryam Davaritouchaee, Amy Nielsen, Rock Mancini, Zhenjia Wang*. pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury, ACS Applied Materials & Interfaces, 2019, 11(18), 16380-16390.

Overseas High-Caliber Personnel Project (Peacock)