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  • 个人简历
  • 教学
  • 研究领域
  • 研究成果
  • 奖励荣誉
  • Biography

    Education

    Sept 2009-Dec 2014 South China University of Technology, Ph.D. in Chemical Engineering

    Oct 2012-Oct 2013 Ludwig-Maximilian University Munich (LUM Munich), Pharmaceutical Science and Technology

    Sept 2005-June 2009 Southwest Minzu University, B.Eng. in Chemical Engineering and Technology


    Professional Experience

    May 2021-present Tsinghua Shenzhen International Graduate School, Assistant Professor

    Jun 2019-Dec 2020 Singapore-MIT Alliance for Research and Technology, Postdoc

    Aug 2016-Jun 2019 Washington State University, Postdoc

    Mar 2015-Aug 2016 National Center for Nanoscience and Technology, Assistant Professor


    Additional Positions

    Guest Editor of International Journal of Polymer Science


    Opening

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  • Current Courses

    Master’s & Ph.D. Advising

    Synthesis of stimuli-responsive biopolymer; development of drug delivery and controlled release system; antimicrobial resistance, uncontrolled inflammation diseases treatment, cancer therapy, immune response regulation

  • Research Interests

    Bioresponsive polymer, targeted drug delivery and controlled release system, and biopharmaceutical science.


    Projects

    Projects of the National Natural Science Foundation of China, United States National Institutes of Health (NIH), Deutsche Forschungsgemeinschaft (DFG), Singapore Agency for Science, Technology and Research (A*Star)


    Research Output

    37 publications, including 26 first/corresponding authored SCI papers in journals such as Science Advances, Advanced Materials, Biomaterials and Journal of Controlled Release. Successfully applied for 7 Chinese patents and 1 US patent.


  • Selected Publications

    [1] Can Yang Zhang, Xinyue Dong, Jin Gao, et al, Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke, Science Advances, 2019, 5(11), eaax7964.

    [2] Can Yang Zhang, Jin Gao, Zhenjia Wang*. Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management. Advanced Materials. 2018, 30(43): 1803618.

    [3] Can Yang Zhang, You Qiang Yang, Tu Xiong Huang, et al. Self-assembled pH-responsive MPEG-b-(PLA-co-PAE) block copolymer micelles for anticancer drug delivery. Biomaterials, 2012, 33: 6273-6283.

    [4] Can Yang Zhang, Wenjing Lin, Jin Gao, et al. pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury, ACS Applied Materials & Interfaces, 2019, 11(18): 16380-16390.

    [5] Can Yang Zhang, Petra Kos, Katharina Müller, et al. Native chemical ligation for conversion of sequence-defined oligomers into targeted pDNA and siRNA carriers. Journal of Controlled Release, 2014, 180: 42-50.

    [6] Can Yang Zhang, Shiyuan Peng, Bin Zhao, et al. Polymeric micelles self-assembled from amphiphilic polymers with twin disulfides used as siRNA carriers to enhance the transfection. Materials Science & Engineering C-Materials for Biological Applications, 2017, 3: 546-552.

    [7] Can Yang Zhang, Di Xiong, Yao Sun, et al. Self-assembled micelles based on pH-sensitive PAE-g-MPEG-Cholesterol block copolymer for anticancer drug delivery. International Journal of Nanomedicine, 2014, 9: 4923-4933.

    [8] Can Yang Zhang, Quan Chen, Wen Sheng Wu, et al. Synthesis and evaluation of cholesterol-grafted PEGylated peptides with pH-triggered property as novel drug carriers for cancer chemotherapy. Colloids and Surfaces B: Biointerfaces, 2016, 11 (142): 55-64.

    [9] Can Yang Zhang, Christina Troiber, Bin Zhao, et al. Self-aseembled amphiphilic sequence-defined PEGylated three-arm oligo (ethanamino) amides via NCL reaction for drug delivery: Impact of building blocks on controlled release. Journal of Controlled Release, 2015, 213: e14-e15.

    [10] Can Yang Zhang, Wen Sheng Wu, Na Yao, et al. pH-Sensitive Amphiphilic Copolymer Brush Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA: Synthesis and Self-Assembled Micelles for Controlled Anti-Cancer Drug Release. RSC Advances, 2014, 4: 40232-40240.

    [11] Yan Wang,  Yuanjun Ma,  Jinping Shi,  et al, Surface modification of monolayer MoS2 by baking for biomedical application, Frontiers in Chemistry, 2020, 8:741.

    [12] Shuguang Zhang,  Peiyao Zhu,  Jiayuan He,  et al,  TME-Responsive Polyprodrug Micelles for Multistage Delivery of Doxorubicin with Improved Cancer Therapeutic Efficacy in Rodents, Advanced Healthcare Materials, 2020, 9(18): 2000387.

    [13] Jinping Shi, Juan Li*, Yan Wang, et al, Recent advances in MoS2-based photothermal therapy for cancer and infectious disease treatment, Journal of Materials Chemistry B, 2020, 8: 5793-5807.

    [14] Juan Li, Yuan Jun Ma, Yan Wang, et al. Dual redox/pH-responsive hybrid polymer-lipid composites: Synthesis, preparation, characterization and application in drug delivery with enhanced therapeutic efficacy. Chemical Engineering Journal. 2018, 341: 450-461.

    [15] Mengzhen Xu#, Can Yang Zhang#, Junguang Wu, et al. PEG-Detachable Polymeric Micelles Self-Assembled from Amphiphilic Copolymers for Tumor-Acidity-Triggered Drug Delivery and Controlled Release, ACS Applied Materials & Interfaces, 2019, 11(6): 5701-5713.


    Books

    Patents

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  • Awards and Honors