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概况
1:基于人工智能(AI)的多靶点抗肿瘤小分子的设计、合成及其活性研究;
2:手性药物导向的不对称催化有机合成方法学研究
教育经历
2008年09月-2013年01月,清华大学,博士
2005年09月-2008年07月,沈阳药科大学,硕士
2001年09月-2005年07月,齐齐哈尔大学,学士
工作经历
2019年08月-至今,清华大学深圳国际研究生院,讲师
2018年03月-2019年08月,清华大学深圳研究生院,讲师
2015年07月-2018年02月,中国科学院大连化学物理研究所与南方科技大学联培,博士后
2013年03月-2015年08月,南方科技大学,Research Fellow(助理研究员)
学术兼职
社会兼职
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教学课程
《合成有机化学》、《有机波谱学》和《药物化学专题实验》
研究生指导
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研究领域
主要研究方向:(1) 基于人工智能(AI)技术的多靶点抗肿瘤小分子化合物的设计、合成及其活性研究;(2) 手性药物导向的过渡金属/小分子协同催化的不对称合成。目前已经在化学类国际一流刊物(J. Am. Chem. Soc. 2024. 146, 34427. Angew. Chem. Int. Ed. 2019, 58, 7092. J. Am. Chem. Soc. 2019, 141, 1074. Chem 2017. 3, 979. Nat. Commun 2017, 8, 14841. J. Am. Chem. Soc. 2016, 138, 9357. Angew. Chem. Int. Ed. 2015, 54, 7847)上发表等文章33篇,其中多篇文章被Chem, Synfacts, Chin. J. Org. Chem.等杂志亮点评述,3篇论文入选高被引论文(top 1%),总被引用1798多次,H-INDEX为20。
主要项目
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代表性论文
[1] Ying-Jie Li #, Zhi-Long Wu#, Qiang-Shuai Gu#, Tingting Fan#, Ming-Hao Duan, Lihong Wu, Yu-Tao Wang, Ji-Peng Wu, Fang-Lei Fu, Fan Sang, Ai-Ting Peng, Yuyang Jiang*, Xin-Yuan Liu*, Jin-Shun Lin*. Catalytic Intermolecular Asymmetric [2π+2σ] Cycloadditions of Bicyclo[1.1.0]butanes: Practical Synthesis of Enantioenriched Highly Substituted Bicyclo[2.1.1]hexanes. J. Am. Chem. Soc. 2024, 146, 34427. (#Co-first author)
Highlighted in Tsinghua University NEWS.
Highlighted in Tsinghua SIGS NEWS.
Highlighted in X-MOL资讯.
Highlighted in CBG资讯
Highlighted in 化学加 资讯
[2] Jin-Shun Lin #, Tao-Tao Li #, Guan-Yuan Jiao #, Qiang-Shuai Gu, Jiang-Tao Cheng, Ling Lv, and XinYuan Liu*. Chiral Brønsted Acid-Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes. Angew. Chem. Int. Ed. 2019, 58, 7092. (#Co-first author)
Highlighted in Synfacts 2019, 15, 662.
[3] Jin-Shun Lin #, Tao-Tao Li #, Ji-Ren Liu #, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Yu-Long Guo, Xin Hong* and Xin-Yuan Liu*. Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three-Component Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes. J. Am. Chem. Soc. 2019, 141, 1074. (#Co-first author)
Highlighted in Synfacts 2019, 15, 0255.
[4] Fu-Li Wang #, Xiao-Yang Dong #, Jin-Shun Lin#, Yang Zeng, Guang-Yuan Jiao, Qiang-Shuai Gu, Xiang-Qi Guo, Can-Liang Ma, Xin-Yuan Liu*. Catalytic Asymmetric Radical Diamination of Alkenes. Chem 2017. 3, 979. (#Co-first author)
Highlighted in Chem 2017, 3, 919.
[5] Jin-Shun Lin #, Fu-Li Wang #, Xiao-Yang Dong #, Wei-Wei He, Yue Yuan, Su Chen, Xin-Yuan Liu*. Catalytic Asymmetric Radical Aminoperfluoroalkylation and Aminodifluoromethylation of Alkenes with Fluoroalkylsulfonyl Chlorides: A Versatile Platform for Enantioenriched-Fluoroalkyl Amines. Nat. Commun. 2017, 8, 14841. (#Co-first author).
[6] Jin-Shun Lin, Xiao-Yang Dong, Tao-Tao Li, Na-Chuan Jiang, Bin Tan, and Xin-Yuan Liu*. A Dual-Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes. J. Am. Chem. Soc. 2016, 138, 9357.
Highlighted in Synfacts, 2016, 12, 1020. Highlighted in Chin. J. Org. Chem. 2016, 36, 2247.
[7] Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* and Xin-Yuan Liu*. Brønsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter. Angew. Chem. Int. Ed. 2015, 54, 7847.
Highlighted in Chin. J. Org. Chem., 2015, 35, 1802.
[8] Lijuan Liu#, Zhichao Shi#, Xun Zhang, Feng Zhan, Jin-Shun Lin,* and Yuyang Jiang*. Synthesis of α-Amino Tertiary Alkylperoxides by Lewis AcidCatalyzed Peroxidation of 1,3,5-Triazines. Chem Asian J. 2021, 16, 3487. (#Co-first author)
[9] Zhichao Shi#, Tingting Fan#, Xun Zhang Feng Zhan, Zhe Wang,Lei Zhao, Jin-Shun Lin* and Yuyang Jiang*. Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5-Triazinanes with Donor-Acceptor Aziridines and Their Anti-Tumor Activity. Adv. Synth. Catal. 2021, 363, 2619. (#Co-first author)
[10] Zhe Wang #, Jiang-Tao Cheng #, Zhichao Shi, Na Wang, Feng Zhan, Sheng-Peng Jiang, Jin-Shun Lin,* Yuyang Jiang,* and Xin-Yuan Liu.* Catalytic Asymmetric Intermolecular RadicalAminotrifluoromethylation of Alkenes with Hydrazines by Cu(I)/CPA Cooperative Catalysis. ChemCatChem 2021, 13, 185. (#Co-first author).
[11] Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu*. Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles. Chem. Eur. J. 2014, 20, 1332.
代表性著作
主要专利成果
其他成果
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荣誉奖项
1.Shenzhen High-level Professional Reserve Talent, Shenzhen, 2020.
2.The winner of SUSTech Presidential Postdoctoral Fellowship (Top 10%), SUSTech, China. 2017.