宋肖炜

宋肖炜，本科与硕士毕业于沈阳药科大学药学院，获药学本科与药物分析学硕士学位，研究方向为中药质量控制与药代动力学。2017年毕业于北京协和医学院/清华大学医学部，获药物分析学博士学位，研究方向为定量质谱成像分析方法及其在空间代谢组学中的应用研究。博士毕业后，先后于2017年8月-2019年12月、2020年1月-2023年11月在复旦大学化学流动站、斯坦福大学化学系继续博士后工作，主要方向为常压原位电离质谱分析新方法及其在临床化学分子诊断的应用研究。2023年12月至2025年12月在以研究科学家身份在斯坦福大学化学系继续工作，研究聚焦于微水液滴与凝聚体液滴驱动的化学分子转化与暗代谢物形成过程研究。

2014年9月-2017年7月，北京协和医学院/清华大学医学部，药物分析专业，博士

2009年9月-2012年7月，沈阳药科大学，药物分析专业，硕士

2005年9月-2009年7月，沈阳药科大学，药学专业，学士

TMR Modern Herbal Medicine 编委、Acta Materia Medica与Metabolites 青年编委、Metabolites客座编辑；Proc. Nat. Acad. Sci., Analytical Chemistry, Rapid Communication Mass Spectrometry, ACS Agricultural Science & Technology, Cancer Cell International等学术期刊审稿人

本人研究方向包括：（1）电喷雾微液滴理化特性及其在界面分子转化、质谱技术方法开发中的应用；（2）基于质量标签策略的多组学质谱流式表征技术；（3）生物液滴细胞器（脂滴与生物凝聚体液滴）介导的代谢转化与暗代谢物发现；（4）原位电离质谱技术方法开发及其在代谢轮廓快速表征与临床疾病分子诊断中的应用；（5）质谱成像空间代谢组技术方法研究及其在临床前药物发现与评价中的应用。主持并参与国家自然科学基金青年基金各1项，主持中国博士后基金面上项目1项。作为空气动力辅助离子化质谱成像装置研发的团队成员，荣获2019 年中国分析测试协会科学技术特等奖。

1. Xiaowei Song, Jinheng Xu, Chenglong Sun, Hongqian Kui, Ruiping Zhang, Zeper Abliz, Richard N.Zare, ACS Measurement Science Au, 2026, (accepted in principle).

2. Xiaowei Song, Chanbasha Basheer, Jinheng Xu, Richard N. Zare, The air–water interfacial nitrogen cycle produces irrigatable-level ammonium nitrate. Chemical Science, 2025, 16 (46), 21815-21824.

3. Xiaowei Song, Juldeh Jallow,  Chanbasha Basheer, Rashed S. Bakdash, Abdullah Alaliwi, Abdulaziz A. Alzamil, Richard N. Zare, Microdroplet-Assisted Synthesis of a Metal Organic Framework Catalyst, Angew. Chemie Int. Ed. 2025, 64 (46), e202515006.

4. Xiaowei Song, Chanbasha Basheer, Jinheng Xu, Muhammad Mustapha Adam, Richard N. Zare, Methane Bubbled through Seawater can be Converted to Methanol with High Efficiency. Advanced Science, 2025, 2412246.

5. Xiaowei Song, Chanbasha Basheer, Jinheng Xu, Richard N.Zare, Onsite Ammonia Synthesis from Water Vapor and Nitrogen in the Air, Science Advance. 2024, 10 (50), eads4443.

6. Xiaowei Song, Povilas Simonis, David Deamer, Richard N. Zare, Wet-dry cycles cause nucleic acid monomers to polymerize into long chains. Proceedings of the National Academy of Sciences. 2024, 121, e2412784121.

7. Xiaowei Song, Chanbasha Basheer, Richard N.Zare, Making Ammonia from Nitrogen and Water Microdroplets. Proceedings of the National Academy of Sciences. 2023, 120(16), p.e2301206120.

8. Xiaowei Song, Xihu Yang, Rahul Narayanan, Vishnu Shankar, Sathiyaraj Ethiraj, Xiang Wang, Ning Duan, Yan-Hong Ni, Qingang Hu, Richard N. Zare*. Oral squamous cell carcinoma diagnosed from saliva metabolic profiling. Proceedings of the National Academy of Sciences. 2020, 117 (28) 16167-16173.

9. Xiaowei Song, Chanbasha Basheer, Richard N.Zare, Water Microdroplets-Initiated Methane Oxidation, Journal of the American Chemical Society, 2023, 145, 27198-27204.

10. Xiaowei Song, Chanbasha Basheer, Richard N.Zare, One-Step Formation of Urea from Carbon Dioxide and Nitrogen Using Water Microdroplets. Journal of the American Chemical Society, 2023, 145, 47, 25910-25916.

11. Xiaowei Song, Yifan Meng, Richard N.Zare, Spraying Water Microdroplets Containing 1, 2, 3-Triazole Converts Carbon Dioxide into Formic Acid. Journal of the American Chemical Society, 2022, 144(37), 16744-16748.

12. Xiaowei Song, Qingce Zang, Chao Li, Tianhao Zhou, Richard N.Zare, Immuno-Desorption Electrospray Ionization Mass Spectrometry Imaging Identifies Functional Macromolecules by Using Microdroplet-Cleavable Mass Tags. Angewandte Chemie Int. Ed. 2023, 135(9), p.e202216969.

13. Xiaowei Song, Chanbasha Basheer, Yu Xia, Richard N.Zare, Oxidation of Ammonia in Water Microdroplets Produces Nitrate and Molecular Hydrogen, Environmental Science and Technology, 2024, 58, 36, 16196–16203.

14. Xiaowei Song, Richard N.Zare, The power of microdroplet photochemistry, Chemical Science, 2024, 15, 3670-3672.

15. Xiaowei Song, Qingce Zang, Jin Zhang, Shanshan Gao, Kailu Zheng, Yan Li, Zeper Abliz, Jiuming He. Metabolic Perturbation Score-based Mass Spectrometry Imaging Spatially Resolves Functional Metabolic Response. Analytical Chemistry. 2023, 95, 17, 6775–6784.

16. Xiaowei Song, Qingce Zang, Richard N Zare. Hydrogen Deuterium Exchange Desorption Electrospray Ionization Mass Spectrometry Visualizes an Acidic Tumor Microenvironment. Analytical Chemistry, 2021, 93 (30): 10411-10417.

17. Xiaowei Song, Jiuming He, Xuechao Pang, Jin Zhang, Chenglong Sun, Luojiao Huang,   Chao Li, Qingce Zang, Xin Li, Zhigang Luo, Ruiping Zhang, Ping Xie, Xiaoyu Liu, Yan Li, Xiaoguang Chen, Zeper Abliz*. Virtual Calibration Mass Spectrometry Imaging For Accurately Mapping Analytes Across Heterogenous Biotissue. Analytical Chemistry. 2019, 91 (4), 2838–2846.

18. Xiaowei Song, Hao Chen, Richard N. Zare*. Conductive Polymer Spray Ionization For Biofluid Analysis. Analytical Chemistry. 2018, 90, 12878-12885.

19. Xiaowei Song, Zhigang Luo, Xin Li, Tiegang Li, Zhonghua Wang, Chenglong Sun, Luojiao Huang, Ping Xie, Xiaoyu Liu, Jiuming He*, Zeper Abliz*. In situ Hydrogel Conditioning of Tissue Samples to Enhance the Drug’s Sensitivity in Ambient Mass Spectrometric Imaging. Analytical Chemistry. 2017, 89, 6318−6323.

软件著作：贺玖明, 再帕尔阿不力孜, 李铁钢, 罗志刚, 黄罗娇, 宋肖炜, 孙成龙, 厉欣, 张瑞萍. 质谱成像代谢组学数据处理软件系统[简称MSI]。登记号：2017SR563585。著作权人：中国医学科学院药物研究所