宋肖炜

宋肖炜，本科与硕士毕业于沈阳药科大学药学院，获药学本科与药物分析学硕士学位，研究方向为中药质量控制与药代动力学。2017年毕业于北京协和医学院/清华大学医学部，获药物分析学博士学位，研究方向为定量质谱成像分析方法及其在空间代谢组学中的应用研究。博士毕业后，先后于2017年8月-2019年12月、2020年1月-2023年11月在复旦大学化学流动站、斯坦福大学化学系继续博士后工作，主要方向为常压原位电离质谱分析新方法及其在临床化学分子诊断的应用研究。2023年12月至2025年12月在以研究科学家身份在斯坦福大学化学系继续工作，研究聚焦于微液滴与凝聚体化学及其在分子与材料合成中的应用研究。2026年1月，以助理教授身份正式入职清华大学深圳国际研究生院-生物医药与健康工程研究院。

2014年9月-2017年7月，北京协和医学院/清华大学医学部，药物分析专业，博士

2009年9月-2012年7月，沈阳药科大学，药物分析专业，硕士

2005年9月-2009年7月，沈阳药科大学，药学专业，学士

TMR Modern Herbal Medicine 编委、Acta Materia Medica与Metabolites 青年编委、Metabolites客座编辑；Proc. Nat. Acad. Sci., Analytical Chemistry, Rapid Communication Mass Spectrometry, ACS Agricultural Science & Technology, Cancer Cell International等学术期刊审稿人

分析化学/仪器分析，质谱, 生物化学分析 (国际院)

本人研究方向包括：

（1）基于质量标签策略的单细胞多组学质谱流式表征技术；

（2）整合介入式微创采样与常压电离质谱技术方法开发及其在临床活检诊断中的应用；

（3）质谱成像与空间多组学方法研究及其在临床疾病诊断、临床前药物研发中的应用；

（4）生物液滴（脂滴与凝聚体）反应器、人工细胞器的构建及其在细胞内功能分子合成中的应用；

（5）生物膜界面组成、结构与功能的质谱表征方法；人工脂质分子与智能响应膜界面的设计构建

主持、参与国家自然科学基金青年基金各1项，主持并结题中国博士后基金面上项目1项。以一作共发表论文29篇，代表性论文包括Nat. Chem. Bio. 1篇，Sci. Adv. 1篇，Proc. Nat. Acad. Sci. 3篇，J. Am. Chem. Soc. 4篇，Angew. Chem. Int. Ed. 2篇， Adv. Sci. 1 篇，Chem. Sci. 2篇，ACS Measurement Science 1篇，Anal. Chem. 5篇，申请中国专利6项（授权4项），美国专利2项，软件著作权1项，作为空气动力辅助离子化质谱成像装置研发的团队成员，荣获2019 年中国分析测试协会科学技术特等奖（5/10）。

1. Xiaowei Song, Yuefeng Ma, Michael W. Chen, Wen Yu, Yan, X.; Jinheng Xu, Lecheng Lyu, Anthony A. Hyman, Yifan Dai, Richard N. Zare, Biomolecular condensates mediate C-N bond formation. Nature Chemical Biology, 2026. (DOI:10.1038/s41589-026-02169-2) (Proofed, ASAP)

2. Xiaowei Song, Lecheng Lyu, Chao Li, Yuefeng Ma, Yanrun Zhou, Yifan Dai, Richard N. Zare, Biomolecular Condensates Power Nitrogen Cycling via Concurrent Redox Activities. Journal of the American Chemical Society, 2026, (DOI: 10.1021/jacs.5c22593)

3. Xiaowei Song, Jinheng Xu, Chenglong Sun, Hongqian Kui, Ruiping Zhang, Zeper Abliz, Richard N.Zare, Dark Reactions in Microdroplets Explain Widespread Artifacts in Metabolomic Profiling, ACS Measurement Science Au, 2026, (DOI: 10.1021/acsmeasuresciau.5c00146).

4. Xiaowei Song, Chanbasha Basheer, Jinheng Xu, Richard N. Zare, The air–water interfacial nitrogen cycle produces irrigatable-level ammonium nitrate. Chemical Science, 2025, 16 (46), 21815-21824.

5. Xiaowei Song, Juldeh Jallow,  Chanbasha Basheer, Rashed S. Bakdash, Abdullah Alaliwi, Abdulaziz A. Alzamil, Richard N. Zare, Microdroplet-Assisted Synthesis of a Metal Organic Framework Catalyst, Angew. Chemie Int. Ed. 2025, 64 (46), e202515006.

6. Xiaowei Song, Chanbasha Basheer, Jinheng Xu, Muhammad Mustapha Adam, Richard N. Zare, Methane Bubbled through Seawater can be Converted to Methanol with High Efficiency. Advanced Science, 2025, 2412246.

7. Xiaowei Song, Chanbasha Basheer, Jinheng Xu, Richard N.Zare, Onsite Ammonia Synthesis from Water Vapor and Nitrogen in the Air, Science Advance. 2024, 10 (50), eads4443.

8. Xiaowei Song, Povilas Simonis, David Deamer, Richard N. Zare, Wet-dry cycles cause nucleic acid monomers to polymerize into long chains. Proceedings of the National Academy of Sciences. 2024, 121, e2412784121.

9. Xiaowei Song, Chanbasha Basheer, Richard N.Zare, Making Ammonia from Nitrogen and Water Microdroplets. Proceedings of the National Academy of Sciences. 2023, 120(16), p.e2301206120.

10. Xiaowei Song, Xihu Yang, Rahul Narayanan, Vishnu Shankar, Sathiyaraj Ethiraj, Xiang Wang, Ning Duan, Yan-Hong Ni, Qingang Hu, Richard N. Zare*. Oral squamous cell carcinoma diagnosed from saliva metabolic profiling. Proceedings of the National Academy of Sciences. 2020, 117 (28) 16167-16173.

11. Xiaowei Song, Chanbasha Basheer, Richard N.Zare, Water Microdroplets-Initiated Methane Oxidation, Journal of the American Chemical Society, 2023, 145, 27198-27204.

12. Xiaowei Song, Chanbasha Basheer, Richard N.Zare, One-Step Formation of Urea from Carbon Dioxide and Nitrogen Using Water Microdroplets. Journal of the American Chemical Society, 2023, 145, 47, 25910-25916.

13. Xiaowei Song, Yifan Meng, Richard N.Zare, Spraying Water Microdroplets Containing 1, 2, 3-Triazole Converts Carbon Dioxide into Formic Acid. Journal of the American Chemical Society, 2022, 144(37), 16744-16748.

14. Xiaowei Song, Qingce Zang, Chao Li, Tianhao Zhou, Richard N.Zare, Immuno-Desorption Electrospray Ionization Mass Spectrometry Imaging Identifies Functional Macromolecules by Using Microdroplet-Cleavable Mass Tags. Angewandte Chemie Int. Ed. 2023, 135(9), p.e202216969.

15. Xiaowei Song, Chanbasha Basheer, Yu Xia, Richard N.Zare, Oxidation of Ammonia in Water Microdroplets Produces Nitrate and Molecular Hydrogen, Environmental Science and Technology, 2024, 58, 36, 16196–16203.

16. Xiaowei Song, Richard N.Zare, The power of microdroplet photochemistry, Chemical Science, 2024, 15, 3670-3672.

17. Xiaowei Song, Qingce Zang, Jin Zhang, Shanshan Gao, Kailu Zheng, Yan Li, Zeper Abliz, Jiuming He. Metabolic Perturbation Score-based Mass Spectrometry Imaging Spatially Resolves Functional Metabolic Response. Analytical Chemistry. 2023, 95, 17, 6775–6784.

18. Xiaowei Song, Qingce Zang, Richard N Zare. Hydrogen Deuterium Exchange Desorption Electrospray Ionization Mass Spectrometry Visualizes an Acidic Tumor Microenvironment. Analytical Chemistry, 2021, 93 (30): 10411-10417.

19. Xiaowei Song, Jiuming He, Xuechao Pang, Jin Zhang, Chenglong Sun, Luojiao Huang,   Chao Li, Qingce Zang, Xin Li, Zhigang Luo, Ruiping Zhang, Ping Xie, Xiaoyu Liu, Yan Li, Xiaoguang Chen, Zeper Abliz*. Virtual Calibration Mass Spectrometry Imaging For Accurately Mapping Analytes Across Heterogenous Biotissue. Analytical Chemistry. 2019, 91 (4), 2838–2846.

20. Xiaowei Song, Hao Chen, Richard N. Zare*. Conductive Polymer Spray Ionization For Biofluid Analysis. Analytical Chemistry. 2018, 90, 12878-12885.

21. Xiaowei Song, Zhigang Luo, Xin Li, Tiegang Li, Zhonghua Wang, Chenglong Sun, Luojiao Huang, Ping Xie, Xiaoyu Liu, Jiuming He*, Zeper Abliz*. In situ Hydrogel Conditioning of Tissue Samples to Enhance the Drug’s Sensitivity in Ambient Mass Spectrometric Imaging. Analytical Chemistry. 2017, 89, 6318−6323.

软件著作：贺玖明, 再帕尔阿不力孜, 李铁钢, 罗志刚, 黄罗娇, 宋肖炜, 孙成龙, 厉欣, 张瑞萍. 质谱成像代谢组学数据处理软件系统[简称MSI]。登记号：2017SR563585。著作权人：中国医学科学院药物研究所