Song Xiaowei

2014/09-2017/07, Peking Union Medical College, Pharmaceutical Analysis, PhD

2009/09-2012/07, Shenyang Pharmaceutical University, Pharmaceutical Analysis, Master

2005/09-2009/07, Shenyang Pharmaceutical University, Pharmacy, Bachelor

2026/01- Tsinghua Shenzhen International Graduate School, Chemical Engineering and Technology, Assistant professor

2023/12-2025/12 Stanford University, Department of Chemistry, Analytical Chemistry, Research Scientist

2020/01-2023/11 Stanford University, Department of Chemistry, Analytical Chemistry, Post-doctor

2017/08-2019/12 Fudan University, Department of Chemistry, Analytical Chemistry, Post-doctor

2012/09-2014/08 Chinese Academy of Medical Science, Institute of Materia Medica, Intern researcher

Editorial Board Member for TMR Modern Herbal Medicine; Young Editorial Board Member for Metabolites, and Acta Materia Medica; Guest Editor for Metabolites; Peer reviewers for Proc. Nat. Acad. Sci., Analytical Chemistry, Rapid Communication Mass Spectrometry, ACS Agricultural Science & Technology, Cancer Cell International.

Analytical Chemistry/Instrumental Analysis, Mass Spectrometry，Biochemical analysis (SIGS)

My research focuses on the following areas:

(1) Mass barcode-based mass spectrometry in single-cell multi-omics characterization

(2) Interventional sampling combined with ambient ionization mass spectrometry (AIMS) in clinical biopsy and in vitro diagnosis.

(3) Mass spectrometry imaging (MSI) for spatial multi-omics and its application in clinical disease diagnosis, preclinical drug research and development

(4) Artificial droplet microreactors and organelles (lipid droplets/biomolecular condensates) and their applications for the in vivo synthesis of functional molecules in cells

(5) MS characterization of biological membrane composition, structure, and functions; Construction of Artificial Lipid Molecules and Smart Response Membrane Interfaces

Grants and Honors:

· Principal Investigator (PI) for one National Natural Science Foundation of China (NSFC) Young Scientists Fund project and one China Postdoctoral Science Foundation General Program.

· Co-Investigator for one National Natural Science Foundation of China (NSFC) project.

· Recipient of the 2019 CAIA Award (Grand Prize) from the China Association for Instrumental Analysis as a core team member in the development of the Air Flow-Assisted Ionization Mass Spectrometry Imaging instrument.

1. Xiaowei Song, Jinheng Xu, Chenglong Sun, Hongqian Kui, Ruiping Zhang, Zeper Abliz, Richard N.Zare, ACS Measurement Science Au, 2026, (accepted in principle).

2. Xiaowei Song, Chanbasha Basheer, Jinheng Xu, Richard N. Zare, The air–water interfacial nitrogen cycle produces irrigatable-level ammonium nitrate. Chemical Science, 2025, 16 (46), 21815-21824.

3. Xiaowei Song, Juldeh Jallow,  Chanbasha Basheer, Rashed S. Bakdash, Abdullah Alaliwi, Abdulaziz A. Alzamil, Richard N. Zare, Microdroplet-Assisted Synthesis of a Metal Organic Framework Catalyst, Angew. Chemie Int. Ed. 2025, 64 (46), e202515006.

4. Xiaowei Song, Chanbasha Basheer, Jinheng Xu, Muhammad Mustapha Adam, Richard N. Zare, Methane Bubbled through Seawater can be Converted to Methanol with High Efficiency. Advanced Science, 2025, 2412246.

5. Xiaowei Song, Chanbasha Basheer, Jinheng Xu, Richard N.Zare, Onsite Ammonia Synthesis from Water Vapor and Nitrogen in the Air, Science Advance. 2024, 10 (50), eads4443.

6. Xiaowei Song, Povilas Simonis, David Deamer, Richard N. Zare, Wet-dry cycles cause nucleic acid monomers to polymerize into long chains. Proceedings of the National Academy of Sciences. 2024, 121, e2412784121.

7. Xiaowei Song, Chanbasha Basheer, Richard N.Zare, Making Ammonia from Nitrogen and Water Microdroplets. Proceedings of the National Academy of Sciences. 2023, 120(16), p.e2301206120.

8. Xiaowei Song, Xihu Yang, Rahul Narayanan, Vishnu Shankar, Sathiyaraj Ethiraj, Xiang Wang, Ning Duan, Yan-Hong Ni, Qingang Hu, Richard N. Zare*. Oral squamous cell carcinoma diagnosed from saliva metabolic profiling. Proceedings of the National Academy of Sciences. 2020, 117 (28) 16167-16173.

9. Xiaowei Song, Chanbasha Basheer, Richard N.Zare, Water Microdroplets-Initiated Methane Oxidation, Journal of the American Chemical Society, 2023, 145, 27198-27204.

10. Xiaowei Song, Chanbasha Basheer, Richard N.Zare, One-Step Formation of Urea from Carbon Dioxide and Nitrogen Using Water Microdroplets. Journal of the American Chemical Society, 2023, 145, 47, 25910-25916.

11. Xiaowei Song, Yifan Meng, Richard N.Zare, Spraying Water Microdroplets Containing 1, 2, 3-Triazole Converts Carbon Dioxide into Formic Acid. Journal of the American Chemical Society, 2022, 144(37), 16744-16748.

12. Xiaowei Song, Qingce Zang, Chao Li, Tianhao Zhou, Richard N.Zare, Immuno-Desorption Electrospray Ionization Mass Spectrometry Imaging Identifies Functional Macromolecules by Using Microdroplet-Cleavable Mass Tags. Angewandte Chemie Int. Ed. 2023, 135(9), p.e202216969.

13. Xiaowei Song, Chanbasha Basheer, Yu Xia, Richard N.Zare, Oxidation of Ammonia in Water Microdroplets Produces Nitrate and Molecular Hydrogen, Environmental Science and Technology, 2024, 58, 36, 16196–16203.

14. Xiaowei Song, Richard N.Zare, The power of microdroplet photochemistry, Chemical Science, 2024, 15, 3670-3672.

15. Xiaowei Song, Qingce Zang, Jin Zhang, Shanshan Gao, Kailu Zheng, Yan Li, Zeper Abliz, Jiuming He. Metabolic Perturbation Score-based Mass Spectrometry Imaging Spatially Resolves Functional Metabolic Response. Analytical Chemistry. 2023, 95, 17, 6775–6784.

16. Xiaowei Song, Qingce Zang, Richard N Zare. Hydrogen Deuterium Exchange Desorption Electrospray Ionization Mass Spectrometry Visualizes an Acidic Tumor Microenvironment. Analytical Chemistry, 2021, 93 (30): 10411-10417.

17. Xiaowei Song, Jiuming He, Xuechao Pang, Jin Zhang, Chenglong Sun, Luojiao Huang,   Chao Li, Qingce Zang, Xin Li, Zhigang Luo, Ruiping Zhang, Ping Xie, Xiaoyu Liu, Yan Li, Xiaoguang Chen, Zeper Abliz*. Virtual Calibration Mass Spectrometry Imaging For Accurately Mapping Analytes Across Heterogenous Biotissue. Analytical Chemistry. 2019, 91 (4), 2838–2846.

18. Xiaowei Song, Hao Chen, Richard N. Zare*. Conductive Polymer Spray Ionization For Biofluid Analysis. Analytical Chemistry. 2018, 90, 12878-12885.

19. Xiaowei Song, Zhigang Luo, Xin Li, Tiegang Li, Zhonghua Wang, Chenglong Sun, Luojiao Huang, Ping Xie, Xiaoyu Liu, Jiuming He*, Zeper Abliz*. In situ Hydrogel Conditioning of Tissue Samples to Enhance the Drug’s Sensitivity in Ambient Mass Spectrometric Imaging. Analytical Chemistry. 2017, 89, 6318−6323.