Tan Ying

    2005-2010, Ph.D. in chemical biology, Central China Normal University

    2001-2005, B.S. in applied chemistry, Central China Normal University

   Oct 2012-present, Lecturer and Associate Professor, Graduate School at Shenzhen,Tsinghua University

    Oct 2016-Oct 2017, Visiting Scholar, National University of Singapore

    Jul 2010-Jul 2012, Postdoctoral Fellow, Guangdong Provincial Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University

Youth Editorial Board Member of Advanced Agrochem and VIEW.

Expert Committee Member of the Recombinant Drugs Branch, China Biochemical Pharmaceutical Industry Association.

Vice Chairman of the Analytical Professional Committee, Shenzhen Pharmaceutical Association.

Interaction between biomacromolecule and small molecules;

Fluorescence-based biosensors using conjugated polyelectrolytes and molecular probes targeting cancer diagnosis and drug mechanism studies;

Computational biology including bioinformatics, biomarker discovery, immunology

Biomedical and Informatics Experiments (Rotation 1)

   Molecular biology

   Cytobiology

   Organic chemistry

Focusing on precision disease diagnosis and treatment, establish a series of non-invasive, highly sensitive, and highly specific disease diagnostic systems and devices; develop drug development systems based on synthetic biology and bioorthogonal chemistry to regulate and intervene in life processes; create novel artificial intelligence algorithms and apply them to multi-omics research, disease diagnosis, and drug design. Lead projects such as the National Natural Science Foundation, Shenzhen Basic Research, while participating in key national research initiatives including the Ministry of Science and Technology's Key R&D Program, National 973 Program, and National 863 Program. Published over 150 papers in journals such as Nature Communications, Advanced Functional Materials, Chem, JACS, Angewandte Chemie, Nature Machine Intelligence, Small, Biosensors & Bioelectronics, and Science China Chemistry.

[1] Jiayi Shi, Huijing Teng, Ziyi Zhang, Yanping Liu, Dan Gao, Jianglei Di, Zijian Yang, Ping Su,* Ying Tan,* Jianshe Ma. Spatial microfluidic holographic integrated platform for label free and high-dimensional analysis of cancer heterogeneity. Nature Communications. 2025, 16:5890.

[2] Teng Zhang, Ying Feng, Cong-Qiao Xu,* Shina Quek, Junqiao Wang, Jun Li, Ying Tan,* Lixin Wu, and Cheuk-Wai So*. An Atomically Precise Alkynyl-Functionalized Silver–Polyoxotungstate Nanocluster with Sandwiched Three-Layer {Ag13}13+ Cluster Architecture and Enhanced Antitumor Activity. Angewandte Chemie International Edition. 2025, e202508288.

[3] Fan Cao, Hongguang Lin, Chen Zhang, Zhimin Cao, Qingfang Li, Pingxia Wang, Ge Gao, Lin Cheng*, Ying Tan* & Liping Cao*. Coordination-Driven [c2] Daisy Chain of Monofunctionalized Tetraphenylethene-Based Hexacationic Cage and Zinc-Porphyrin Toward Photocatalysis-Assisted Photodynamic Therapy. CCS Chemistry, 2025, DOI: 10.31635/ccschem.025.202505526.

[4] Zheng-Xin Zhou, Yue-Liu-Ting Fu, Chen Zhang, Yuan-Heng Li, Bin-Jun Zhang, Yu-Qing Xiao, Yu-Jie Li, Li-Yan Chen, Li Rao,* Ying Tan,* Wen-Jing Xiao, and Liang-Qiu Lu*. Modular Synthesis of Planar-Chiral Cyclononenes via trans-Retentive Trapping of π‑Allyl-Pd Dipoles. Journal of the American Chemical Society, 2025,  147, 3223−3232.

[5] Ying Feng, Zhilin Zhang, Haowei Zhang, Hui Guo, Chunyan Tan, Naihan Xu,* Ying Tan,* and Yuyang Jiang. Aptamer Proteolysis-Targeting Chimeras (PROTACs): A Novel Strategy to Combat Drug Resistance in Estrogen Receptor α-Positive Breast Cancer. ACS Pharmacology & Translational Science, 2024, 7, 3945-3954.

[6] Yu-Qing Xiao, Kai-Xin Fang, Zhihan Zhang, Chen Zhang, Yu-Jie Li, Bao-Cheng Wang, Bin-Jun Zhang, Yu-Qing Jiang, Miao Zhang, Ying Tan*, Wen-Jing Xiao and Liang-Qiu Lu*, Hyperconjugation-Driven Isodesmic Reaction of Indoles and Anilines: Reaction Discovery, Mechanism Study, and Antitumor Application. Angewandte Chemie International Edition. 2024, e202408426.

[7] Chen Zhang, Junqiao Wang, Hui Chen, Muzi Ouyang, Yuanheng Li, Chunyan Tan, Yuyang Jiang, and Ying Tan*. A Therapeutic Pretargeting Strategy for Triple-Negative Breast Cancer Based on a Bioorthogonal Reaction and a Self-Assembled Peptide. Advanced Functional Materials, 2024, 2313090.

[8] Xiaoqi Xue, Chen Zhang, Xiaolin Li, Junqiao Wang, Haowei Zhang, Ying Feng, Naihan Xu, Hongyan Li, Chunyan Tan, Yuyang Jiang, Ying Tan*. mRNA PROTACs: engineering PROTACs for high-efficiency targeted protein degradation. MedComm. 2024, 5:e478. (封面文章）

[9] Hui Chen, Ying Feng, Feng Liu, Chunyan Tan, Naihan Xu, Yuyang Jiang,** Ying Tan*. Universal smartphone-assisted label-free CRISPR/Cas12a-DNAzyme chemiluminescence biosensing platform for on-site detection of nucleic acid and non-nucleic acid targets. Biosensors and Bioelectronics, 2024, 247, 115929.

[10] Muzi Ouyang, Ying Feng, Hui Chen, Yanping Liu, Chunyan Tan, and Ying Tan*. Recent Advances in Optically Controlled PROTAC, Bioengineering, 2023, 10, 1368.

[11] Dongyang Li, Tianruo Shen, Xiaoqi Xue, Weijie Chen, Wenjun Tao, Weijie Chi, Sheng Hua Liu, Ying Tan*, Xiaogang Liu*, Jun Yin*. Synergistic effects of multiple rotors and hydrogen-bond interactions lead to sensitive near-infrared viscosity probes for live-cell microscopy. Science China Chemistry, 2023, 66: 2329-2338.

[12] Kai Ping Cheng, Wan Xiang Shen, Yu Yang Jiang, Yan Chen, Yu Zong Chen,* Ying Tan*. Deep learning of 2D-Restructured gene expression representations for improved low-sample therapeutic response prediction. Computers in Biology and Medicine. 2023, 164, 107245.

[13] Bao-Cheng Wang, Li Rao, Kai-Xin Fang, Bao-Le Qu, Fen-Ya Xiong, Ying Feng, Ying Tan,* Liang-Qiu Lu,* and Wen-Jing Xiao. Dearomatization-Rearomatization Reaction of Metal-Polarized Aza-ortho-Quinone Methides. Angewandte Chemie International Edition. 2023, e202301592.

[14] Chen Li, Hui Chen, Tingting Fan, Jingru Zhao, Zheng Ding, Zeyu Lin, Shuqing Sun, Chunyan Tan, Feng Liu, Hongtao Jian*, Ying Tan*. A visualized automatic particle counting strategy for single-cell level telomerase activity quantification. VIEW, 2023, 20220078. (cover paper）

[15] Bao-Cheng Wang, Tingting Fan, Fen-Ya Xiong, Peng Chen, Kai-Xin Fang, Ying Tan,* Liang-Qiu Lu,* and Wen-Jing Xiao De Novo Construction of Chiral Aminoindolines by Cu-Catalyzed Asymmetric Cyclization and Subsequent Discovery of an Unexpected Sulfonyl Migration. Journal of the American Chemical Society, 2022, 144, 19932-19941.

[16] Xinyan Zhang, Zhilin Zhang, Xiaoqi Xue, Tingting Fan, Chunyan Tan, Feng Liu, Ying Tan,* and Yuyang Jiang. PROTAC Degrader of Estrogen Receptor α Targeting DNA-Binding Domain in Breast Cancer. ACS Pharmacology & Translational Science, 2022, 5, 1109-1118.

[17] Junyue Chen, Gerile Oudeng, Hongtao Feng, Sixi Liu, Hung-Wing Li, Yi-Ping Ho, Yan Chen,* Ying Tan,* and Mo Yang*. 2D MOF Nanosensor-Integrated Digital Droplet Microfluidic Flow Cytometry for In Situ Detection of Multiple miRNAs in Single CTC Cells. Small, 2022, 2201779. 

2005-2010, Ph.D. in chemical biology, Central China Normal University

2001-2005, B.S. in applied chemistry, Central China Normal University

Oct 2012-present, Lecturer and Associate Professor, Graduate School at Shenzhen,Tsinghua University

Oct 2016-Oct 2017, Visiting Scholar, National University of Singapore

Jul 2010-Jul 2012, Postdoctoral Fellow, Guangdong Provincial Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University

2021 Excellent Teacher of Shenzhen；

Third prize in the 9th Tsinghua University Young Teachers Teaching Competition；

Excellent Master thesis advisor of Tsinghua University